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Linking novelty seeking and harm avoidance personality traits to basal ganglia: volumetry and mean diffusivity

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Abstract

Novelty Seeking (NS) and Harm Avoidance (HA) temperamental traits are related to approaching or avoiding motivational circuits relying on the integrity and functionality of distributed brain areas implicated in arousal and action. The present study verified whether and how macro- and micro-structural variations of basal ganglia are correlated with scores obtained in the NS and HA temperamental scales of the Temperament and Character Inventory by Cloninger. To this aim, 125 healthy adults aged 18–67 years of both sexes completed the Temperament and Character Inventory and underwent a high-resolution T1-weighted magnetic resonance imaging and a diffusion tensor imaging using a 3T scanner. The scores obtained in the temperamental scales were associated with volumes, mean diffusivity and fractional anisotropy measures of basal ganglia of both hemispheres separately, by using linear regression analyses. We found increased bilateral caudate and pallidum volumes associated with higher NS scores, as well as increased mean diffusivity in the bilateral putamen associated with higher HA scores. Macro- and micro-structural variations of basal ganglia regions contribute to explain the biological variance associated with NS or HA personality phenotype. The present findings evidencing some brain-temperament relationships highlight the importance of obtaining macro- and micro-structural measures in relation to individual differences.

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Acknowledgments

The authors would like to thank Prof. Fabio Ferlazzo for his kind and expert support in statistical analyses.

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The authors declare that they have no conflict of interest.

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  1. I.R.C.C.S. Santa Lucia Foundation, Via Ardeatina 306, 00142, Rome, Italy

    Daniela Laricchiuta, Laura Petrosini, Fabrizio Piras, Debora Cutuli, Enrica Macci, Eleonora Picerni, Chiara Chiapponi, Carlo Caltagirone & Gianfranco Spalletta

  2. Department of Psychology, Faculty of Medicine and Psychology, University “Sapienza” of Rome, Via dei Marsi 78, 00185, Rome, Italy

    Daniela Laricchiuta, Laura Petrosini, Debora Cutuli & Eleonora Picerni

  3. Department of Neuroscience, Tor Vergata University, Via Montpellier 1, 00135, Rome, Italy

    Carlo Caltagirone

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  1. Daniela Laricchiuta
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Laricchiuta, D., Petrosini, L., Piras, F. et al. Linking novelty seeking and harm avoidance personality traits to basal ganglia: volumetry and mean diffusivity. Brain Struct Funct 219, 793–803 (2014). https://doi.org/10.1007/s00429-013-0535-5

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