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Present and future role of FDG-PET/CT imaging in the management of head and neck carcinoma

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Abstract

Integrated positron emission tomography/computed tomography (PET/CT) with 2-[18F]fluoro-2-deoxy-d-glucose (FDG) is a useful technique for acquisition of both glucose metabolic and anatomic imaging data using a single device in a single diagnostic session, and has opened a new field in clinical oncologic imaging. FDG-PET/CT has been used successfully for the initial staging, restaging, monitoring of the response to therapy, and prognostication of head and neck carcinoma. The present review discusses the current role of FDG-PET/CT in the management of head and neck carcinoma, focusing on its usefulness and limitations for imaging in these patients.

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References

  1. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology™ 2014. Head and neck cancers v. 2. 2014. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp#headand-neck. Accessed 26 Oct 2015

  2. Fleming AJ Jr, Smith SP Jr, Paul CM, Hall NC, Daly BT, Agrawal A, et al. Impact of [18F]-2-fluorodeoxyglucose-positron emission tomography/computed tomography on previously untreated head and neck cancer patients. Laryngoscope. 2007;117:1173–9.

    Article  PubMed  Google Scholar 

  3. Gordin A, Golz A, Keidar Z, Daitzchman M, Bar-Shalom R, Israel O. The role of FDG-PET/CT imaging in head and neck malignant conditions: impact on diagnostic accuracy and patient care. Otolaryngol Head Neck Surg. 2007;137:130–7.

    Article  PubMed  Google Scholar 

  4. Connell CA, Corry J, Milner AD, Hogg A, Hicks RJ, Rischin D, et al. Clinical impact of, and prognostic stratification by, F-18 FDG PET/CT in head and neck mucosal squamous cell carcinoma. Head Neck. 2007;29:986–95.

    Article  PubMed  Google Scholar 

  5. Veit-Haibach P, Luczak C, Wanke I, Fischer M, Egelhof T, Beyer T, et al. TNM staging with FDG-PET/CT in patients with primary head and neck cancer. Eur J Nucl Med Mol Imaging. 2007;34:1953–62.

    Article  PubMed  Google Scholar 

  6. Kim SY, Roh JL, Yeo NK, Kim JS, Lee JH, Choi SH, et al. Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Ann Oncol. 2007;18:1698–703.

    Article  PubMed  CAS  Google Scholar 

  7. Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, et al. Head and neck squamous cell carcinoma (HNSCC)—detection of synchronous primaries with 18F-FDG-PET/CT. Eur J Nucl Med Mol Imaging. 2009;36:919–27.

    Article  PubMed  Google Scholar 

  8. Yoo J, Henderson S, Walker-Dilks C. Evidence-based guideline recommendations on the use of positron emission tomography imaging in head and neck cancer. Clin Oncol ( Coll Radiol. 2013;25:e33–66.

    Article  CAS  Google Scholar 

  9. Lonneux M, Hamoir M, Reychler H, Maingon P, Duvillard C, Calais G, et al. Positron emission tomography with [18F]fluorodeoxyglucose improves staging and patient management in patients with head and neck squamous cell carcinoma: a multicenter prospective study. J Clin Oncol. 2010;28:1190–5.

    Article  PubMed  CAS  Google Scholar 

  10. Becker M, Zbären P, Casselman JW, Kohler R, Dulguerov P, Becker CD. Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 2008;249:551–9.

    Article  PubMed  Google Scholar 

  11. Becker M, Burkhardt K, Dulguerov P, Allal A. Imaging of the larynx and hypopharynx. Eur J Radiol. 2008;66:460–79.

    Article  PubMed  Google Scholar 

  12. Paes FM, Singer AD, Checkver AN, Palmquist RA, De La Vega G, Sidani C. Perineural spread in head and neck malignancies: clinical significance and evaluation with 18F-FDG PET/CT. Radiographics. 2013;33:1717–36.

    Article  PubMed  Google Scholar 

  13. Snow GB, Patel P, Leemans CR, Tiwari R. Management of cervical lymph nodes in patients with head and neck cancer. Eur Arch Otorhinolaryngol. 1992;249:187–94.

    Article  PubMed  CAS  Google Scholar 

  14. Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg. 1990;160:405–9.

    Article  PubMed  CAS  Google Scholar 

  15. Castelijins JA, van den Brekel MW. Imaging of lymphadenopathy in the neck. Eur Radiol. 2002;12:727–38.

    Article  Google Scholar 

  16. Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, et al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005;46:1136–43.

    PubMed  Google Scholar 

  17. Schöder H, Carlson DL, Kraus DH, Stambuk HE, Gönen M, Erdi YE, et al. 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. J Nucl Med. 2006;47:755–62.

    PubMed  Google Scholar 

  18. Murakami R, Uozumi H, Hirai T, Nishimura R, Shiraishi S, Ota K, et al. Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007;68:377–82.

    Article  PubMed  Google Scholar 

  19. Jeong HS, Baek CH, Son YI, Ki Chung M, Kyung Lee D, Young Choi J, et al. Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma. Head Neck. 2007;29:203–10.

    Article  PubMed  Google Scholar 

  20. Nabmias C, Carlson ER, Duncan LD, Blodgett TM, Kennedy J, Long MJ, et al. Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer. J Oral Maxillofac Surg. 2007;65:2524–35.

    Article  Google Scholar 

  21. Roh JL, Yeo NK, Kim JS, Lee JH, Cho KJ, Choi SH, et al. Utility of 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography and positron emission tomography/computed tomography imaging in the preoperative staging of head and neck squamous cell carcinoma. Oral Oncol. 2007;43:887–93.

    Article  PubMed  Google Scholar 

  22. Yamazaki Y, Saitoh M, Notani K, Tei K, Totsuka Y, Takinami S, et al. Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer. Ann Nucl Med. 2008;22:177–84.

    Article  PubMed  Google Scholar 

  23. Krabbe CA, Dijkstra PU, Pruim J, van der Laan BF, van der Wal JE, Gravendeel JP, et al. FDG PET in oral and oropharyngeal cancer. Value for confirmation of N0 neck and detection of occult metastases. Oral Oncol. 2008;44:31–6.

    Article  PubMed  Google Scholar 

  24. Piao Y, Bold B, Tayier A, Ishida R, Omura K, Okada N, et al. Evaluation of 18F-FDG PET/CT for diagnosing cervical nodal metastases in patients with oral cavity or oropharynx carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:933–8.

    Article  PubMed  Google Scholar 

  25. Yoon DY, Hwang HS, Chang SK, Rho YS, Ahn HY, Kim JH, et al. CT, MR, US,18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck. Eur Radiol. 2009;19:634–42.

    Article  PubMed  Google Scholar 

  26. Richard C, Prevot N, Timoshenko AP, Dumollard JM, Dubois F, Martin C, et al. Preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography imaging in head and neck cancer: does it really improve initial N staging? Acta Otolaryngol. 2010;130:1421–4.

    Article  PubMed  Google Scholar 

  27. Iyer NG, Clark JR, Singham S, Zhu J. Role of pretreatment 18FDG-PET/CT in surgical decision-making for head and neck cancers. Head Neck. 2010;32:1202–8.

    Article  PubMed  Google Scholar 

  28. Kim SY, Kim JS, Doo H, Lee H, Lee JH, Cho KJ, et al. Combined [18F]fluorodeoxyglucose positron emission tomography and computed tomography for detecting contralateral neck metastases in patients with head and neck squamous cell carcinoma. Oral Oncol. 2011;47:376–80.

    Article  PubMed  Google Scholar 

  29. Matsubara R, Kawano S, Chikui T, Kiyosue T, Goto Y, Hirano M, et al. Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma. Acad Radiol. 2012;19:708–17.

    Article  PubMed  Google Scholar 

  30. Nguyen A, Luginbuhl A, Cognetti D, Van Abel K, Bar-Ad V, Intenzo C, et al. Effectiveness of PET/CT in the preoperative evaluation of neck disease. Laryngoscope. 2014;124:159–64.

    Article  PubMed  Google Scholar 

  31. Roh JL, Park JP, Kim JS, Lee JH, Cho KJ, Choi SH, et al. 18F fluorodeoxyglucose PET/CT in head and neck squamous cell carcinoma with negative neck palpation findings: a prospective study. Radiology. 2014;271:153–61.

    Article  PubMed  Google Scholar 

  32. Joo YH, Yoo IR, Cho KJ, Park JO, Nam IC, Kim CS, et al. The value of preoperative 18F-FDG PET/CT for assessing the contralateral neck in head and neck cancer patients with unilateral node metastasis (N1-3). Clin Otolaryngol. 2014;39:338–44.

    Article  PubMed  Google Scholar 

  33. Kyzas PA, Evangelou E, Denaxa-Kyza D, Ioannidis JP. 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst. 2008;100:712–20.

    Article  PubMed  Google Scholar 

  34. Sun R, Tang X, Yang Y, Zhang C. 18FDG-PET/CT for the detection of regional nodal metastasis in patients with head and neck cancer: a meta-analysis. Oral Oncol. 2015;51:314–20.

    Article  PubMed  Google Scholar 

  35. Xu GZ, Zhu XD, Li MY. Accuracy of whole-body PET and PET-CT in initial M staging of head and neck cancer: a meta-analysis. Head Neck. 2011;33:87–94.

    Article  PubMed  Google Scholar 

  36. Jereczek-Fossa BA, Jassem J, Orecchia R. Cervical lymph node metastases of squamous cell carcinoma from an unknown primary. Cancer Treat Rev. 2004;30:153–64.

    Article  PubMed  Google Scholar 

  37. Yabuki K, Tsukuda M, Horiuchi C, Taguchi T, Nishimura G. Role of 18F-FDG PET in detecting primary site in the patient with primary unknown carcinoma. Eur Arch Otorhinolaryngol. 2010;267:1785–92.

    Article  PubMed  Google Scholar 

  38. Wong WL, Sonoda LI, Gharpurhy A, Gollub F, Wellsted D, Goodchild K, et al. 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the assessment of occult primary head and neck cancers—an audit and review of published studies. Clin Oncol R Coll Radiol. 2012;24:190–5.

    Article  PubMed  CAS  Google Scholar 

  39. Lee JR, Kim JS, Roh JL, Lee JH, Baek JH, Cho KJ, et al. Detection of occult primary tumors in patients with cervical metastases of unknown primary tumors: comparison of 18F FDG PET/CT with contrast-enhanced CT or CT/MR imaging—prospective study. Radiology. 2015;274:764–71.

    Article  PubMed  Google Scholar 

  40. Van Rees BP, Cleton-Jansen AM, Cense HA, Polak MM, Clement MJ, Drillenburg P, et al. Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract. Hum Pathol. 2000;31:269–71.

    Article  PubMed  Google Scholar 

  41. Su YY, Fang FM, Chuang HC, Luo SD, Chien CY. Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopy. Head Neck. 2010;32:780–5.

    PubMed  Google Scholar 

  42. Nakaminato S, Toriihara A, Makino T, Kawano T, Kishimoto S, Shibuya H. Prevalence of esophageal cancer during the pretreatment of hypopharyngeal cancer patients: routinely performed esophagogastroduodenoscopy and FDG-PET/CT findings. Acta Oncol. 2012;51:645–52.

    Article  PubMed  Google Scholar 

  43. Xu GZ, Guan DJ, He ZY. 18FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis. Oral Oncol. 2011;47:560–5.

    Article  PubMed  Google Scholar 

  44. Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51:571–8.

    Article  PubMed  CAS  Google Scholar 

  45. Lell M, Baum U, Greess H, Nömayr A, Nkenke E, Koester M, et al. Head and neck tumors: imaging recurrent tumor and post-therapeutic changes with CT and MRI. Eur J Radiol. 2000;33:239–47.

    Article  PubMed  CAS  Google Scholar 

  46. Salaun PY, Abgral R, Querellou S, Couturier O, Valette G, Bizais Y, et al. Does 18fluoro-fluorodeoxyglucose positron emission tomography improve recurrence detection in patients treated for head and neck squamous cell carcinoma with negative clinical follow-up? Head Neck. 2007;29:1115–20.

    Article  PubMed  Google Scholar 

  47. Branstetter BF 4th, Blodgett TM, Zimmer LA, Snyderman CH, Johnson JT, Raman S, et al. Head and neck malignancy: is PET/CT more accurate than PET or CT alone? Radiology. 2005;235:580–6.

    Article  PubMed  Google Scholar 

  48. Ryan WR, Fee WE Jr, Le QT, Pinto HA. Positron-emission tomography for surveillance of head and neck cancer. Laryngoscope. 2005;115:645–50.

    Article  PubMed  Google Scholar 

  49. Nayak JV, Walvekar RR, Andrade RS, Daamen N, Lai SY, Argiris A, et al. Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CT. Laryngoscope. 2007;117:2129–34.

    Article  PubMed  Google Scholar 

  50. Halpern BS, Yeom K, Fueger BJ, Lufkin RB, Czernin J, Allen-Auerbach M. Evaluation of suspected local recurrence in head and neck cancer: a comparison between PET and PET/CT for biopsy proven lesions. Eur J Radiol. 2007;62:199–204.

    Article  PubMed  Google Scholar 

  51. Kim SY, Lee SW, Nam SY, Im KC, Kim JS, Oh SJ, et al. The feasibility of 18F-FDG PET scans 1 month after completing radiotherapy of squamous cell carcinoma of the head and neck. J Nucl Med. 2007;48:373–8.

    PubMed  CAS  Google Scholar 

  52. Lee JC, Kim JS, Lee JH, Nam SY, Choi SH, Lee SW, et al. F-18 FDG-PET as a routine surveillance tool for the detection of recurrent head and neck squamous cell carcinoma. Oral Oncol. 2007;43:686–92.

    Article  PubMed  CAS  Google Scholar 

  53. Comoretto M, Balestreri L, Borsatti E, Cimitan M, Franchin G, Lise M. Detection and restaging of residual and/or recurrent nasopharyngeal carcinoma after chemotherapy and radiation therapy: comparison of MR imaging and FDG PET/CT. Radiology. 2008;249:203–11.

    Article  PubMed  Google Scholar 

  54. Ong SC, Schöder H, Lee NY, Patel SG, Carlson D, Fury M, et al. Clinical utility of 18F-FDG PET/CT in assessing the neck after concurrent chemoradiotherapy for locoregional advanced head and neck cancer. J Nucl Med. 2008;49:532–40.

    Article  PubMed  Google Scholar 

  55. Krabbe CA, Pruim J, Dijkstra PU, Balink H, van der Laan BF, de Visscher JG, et al. 18F-FDG PET as a routine posttreatment surveillance tool in oral and oropharyngeal squamous cell carcinoma: a prospective study. J Nucl Med. 2009;50:1940–7.

    Article  PubMed  Google Scholar 

  56. Rabalais AG, Walvekar R, Nuss D, McWhorter A, Wood C, Fields R, et al. Positron emission tomography-computed tomography surveillance for the node-positive neck after chemoradiotherapy. Laryngoscope. 2009;119:1120–4.

    Article  PubMed  Google Scholar 

  57. Gourin CG, Watts T, Williams HT, Patel VS, Bilodeau PA, Coleman TA. Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer. Laryngoscope. 2009;119:703–6.

    Article  PubMed  Google Scholar 

  58. Kao J, Vu HL, Genden EM, Mocherla B, Park EE, Packer S, et al. The diagnostic and prognostic utility of positron emission tomography/computed tomography-based follow-up after radiotherapy for head and neck cancer. Cancer. 2009;115:4586–94.

    Article  PubMed  Google Scholar 

  59. Abgral R, Querellou S, Potard G, Le Roux PY, Le Duc-Pennec A, Marianovski R, et al. Does 18F-FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up? J Nucl Med. 2009;50:24–9.

    Article  PubMed  Google Scholar 

  60. Yao M, Smith RB, Hoffman HT, Funk GF, Lu M, Menda Y, et al. Clinical significance of postradiotherapy [18F]-fluorodeoxyglucose positron emission tomography imaging in management of head-and-neck cancer—a long-term outcome report. Int J Radiat Oncol Biol Phys. 2009;74:9–14.

    Article  PubMed  CAS  Google Scholar 

  61. Kim SY, Kim JS, Yi JS, Lee JH, Choi SH, Nam SY, et al. Evaluation of 18F-FDG PET/CT and CT/MRI with histopathologic correlation in patients undergoing salvage surgery for head and neck squamous cell carcinoma. Ann Surg Oncol. 2011;18:2579–84.

    Article  PubMed  Google Scholar 

  62. Zundel MT, Michel MA, Schultz CJ, Maheshwari M, Wong SJ, Campbell BH, et al. Comparison of physical examination and fluorodeoxyglucose positron emission tomography/computed tomography 4–6 months after radiotherapy to assess residual head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011;81:e825–32.

    Article  PubMed  Google Scholar 

  63. Zhang I, Branstetter BF 4th, Beswick DM, Maxwell JH, Gooding WE, Ferris RL. The benefit of early PET/CT surveillance in HPV-associated head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2011;137:1106–11.

    Article  PubMed  Google Scholar 

  64. Yi JS, Kim JS, Lee JH, Choi SH, Nam SY, Kim SY, et al. 18F-FDG PET/CT for detecting distant metastases in patients with recurrent head and neck squamous cell carcinoma. J Surg Oncol. 2012;106:708–12.

    Article  PubMed  Google Scholar 

  65. Beswick DM, Gooding WE, Johnson JT, Branstetter BF 4th. Temporal patterns of head and neck squamous cell carcinoma recurrence with positron-emission tomography/computed tomography monitoring. Laryngoscope. 2012;122:1512–7.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Kostakoglu L, Fardanesh R, Posner M, Som P, Rao S, Park E, et al. Early detection of recurrent disease by FDG-PET/CT leads to management changes in patients with squamous cell cancer of the head and neck. Oncologist. 2013;18:1108–17.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Ho AS, Tsao GJ, Chen FW, Shen T, Kaplan MJ, Colevas AD, et al. Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence. Cancer. 2013;119:1349–56.

    Article  PubMed  Google Scholar 

  68. Rangaswamy B, Fardanesh MR, Genden EM, Park EE, Fatterpekar G, Patel Z, et al. Improvement in the detection of locoregional recurrence in head and neck malignancies: F-18 fluorodeoxyglucose-positron emission tomography/computed tomography compared to high-resolution contrast-enhanced computed tomography and endoscopic examination. Laryngoscope. 2013;123:2664–9.

    Article  PubMed  Google Scholar 

  69. Dunsky KA, Wehrmann DJ, Osman MM, Thornberry BM, Varvares MA. PET-CT and the detection of the asymptomatic recurrence or second primary lesions in the treated head and neck cancer patient. Laryngoscope. 2013;123:2161–4.

    Article  PubMed  CAS  Google Scholar 

  70. Kim JW, Roh JL, Kim JS, Lee JH, Cho KJ, Choi SH, et al. 18F-FDG PET/CT surveillance at 3–6 and 12 months for detection of recurrence and second primary cancer in patients with head and neck squamous cell carcinoma. Br J Cancer. 2013;109:2973–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  71. Koshkareva Y, Branstetter BF 4th, Gaughan JP, Ferris RL. Predictive accuracy of first post-treatment PET/CT in HPV-related oropharyngeal squamous cell carcinoma. Laryngoscope. 2014;124:1843–7.

    Article  PubMed  Google Scholar 

  72. Robin P, Abgral R, Valette G, Le Roux PY, Keromnes N, Rousset J, et al. Diagnostic performance of FDG PET/CT to detect subclinical HNSCC recurrence 6 months after the end of treatment. Eur J Nucl Med Mol Imaging. 2015;42:72–8.

    Article  PubMed  CAS  Google Scholar 

  73. Suenaga Y, Kitajima K, Ishihara T, Sasaki R, Otsuki N, Nibu KI, et al. FDG-PET/contrast-enhanced CT as a post-treatment tool in head and neck squamous cell carcinoma: comparison with FDG-PET/non-contrast-enhanced CT and contrast-enhanced CT. Eur Radiol. 2015 [Epub ahead of print].

  74. Isles MG, McConkey C, Mehanna HM. A systematic review and meta-analysis of the role of positron emission tomography in the follow-up of head and neck squamous cell carcinoma following radiotherapy or chemoradiotherapy. Clin Otolaryngol. 2008;33:210–22.

    Article  PubMed  CAS  Google Scholar 

  75. Gupta T, Master Z, Kannan S, Agarwal JP, Ghsoh-Laskar S, Rangarajan V, et al. Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head and neck cancer: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2011;38:2083–95.

    Article  PubMed  Google Scholar 

  76. Kawabe J, Higashiyama S, Yoshida A, Kotani K, Shiomi S. The role of FDG PET-CT in the therapeutic evaluation for HNSCC patients. Jpn J Radiol. 2012;30:463–70.

    Article  PubMed  CAS  Google Scholar 

  77. Paidpally V, Tahari AK, Lam S, Alluri K, Marur S, Koch W, et al. Addition of 18F-FDG PET/CT to clinical assessment predicts overall survival in HNSCC: a retrospective analysis with follow-up for 12 years. J Nucl Med. 2013;54:2039–45.

    Article  PubMed  CAS  Google Scholar 

  78. Gao S, Li S, Yang X, Tang Q. 18FDG PET-CT for distant metastases in patients with recurrent head and neck cancer after definitive treatment. A meta-analysis. Oral Oncol. 2014;50:163–7.

    Article  PubMed  CAS  Google Scholar 

  79. Porceddu SV, Pryor DI, Burmeister E, Burmeister BH, Poulsen MG, Foote MC, et al. Results of a prospective study of positron emission tomography-directed management of residual nodal abnormalities in node-positive head and neck cancer after definitive radiotherapy with or without systemic therapy. Head Neck. 2011;33:1675–82.

    Article  PubMed  Google Scholar 

  80. Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, et al. Prospective risk-adjusted [18F]fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol. 2009;27:2509–15.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Kitagawa Y, Nishizawa S, Sano K, Ogasawara T, Nakamura M, Sadato N, et al. Prospective comparison of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67 Ga scintigraphy) in assessment of combined intra-arterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med. 2003;44:198–206.

    PubMed  Google Scholar 

  82. Andrade RS, Heron DE, Degirmenci B, Filho PA, Branstetter BF, Seethala RR, et al. Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers. Int J Radiat Oncol Biol Phys. 2006;65:1315–22.

    Article  PubMed  Google Scholar 

  83. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Eng J Med. 2003;349:2091–8.

    Article  CAS  Google Scholar 

  84. Brun E, Kjellén E, Tennvall J, Ohlsson T, Sandell A, Perfekt R, et al. FDG PET studies during treatment: prediction of therapy outcome in head and neck squamous cell carcinoma. Head Neck. 2002;24:127–35.

    Article  PubMed  Google Scholar 

  85. Kishino T, Hoshikawa H, Nishiyama Y, Yamamoto Y, Mori N. Usefulness of 3′-deoxy-3′-18F-fluorothymidine PET for predicting early response to chemoradiotherapy in head and neck cancer. J Nucl Med. 2012;53:1521–7.

    Article  PubMed  CAS  Google Scholar 

  86. Minn H, Clavo AC, Grenman R, Wahl RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and l-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med. 1995;36:252–8.

    PubMed  CAS  Google Scholar 

  87. Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-d-glucose. Int J Radiat Oncol Biol Phys. 2004;59:1295–300.

    Article  PubMed  CAS  Google Scholar 

  88. Roh JL, Pae KH, Choi SH, Kim JS, Lee S, Kim SB, et al. 2-[18F]-Fluoro-2-deoxy-d-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol. 2007;33:790–5.

    Article  PubMed  Google Scholar 

  89. Machtay M, Natwa M, Andrel J, Hyslop T, Anne PR, Lavarino J, et al. Pretreatment FDG-PET standardized uptake value as a prognostic factor for outcome in head and neck cancer. Head Neck. 2009;31:195–201.

    Article  PubMed  Google Scholar 

  90. Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Naitou K, Ueda Y, et al. Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. AJR Am J Roentgenol. 2009;192:W156–60.

    Article  PubMed  Google Scholar 

  91. Suzuki K, Nishioka T, Homma A, Tsuchiya K, Yasuda M, Aoyama H, et al. Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer: does the standardized uptake value predict treatment outcome? Jpn J Radiol. 2009;27:237–42.

    Article  PubMed  Google Scholar 

  92. Zhang B, Li X, Lu X. Standardized uptake value is of prognostic value for outcome in head and neck squamous cell carcinoma. Acta Otolaryngol. 2010;130:756–62.

    Article  PubMed  Google Scholar 

  93. Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ, et al. Validation that metabolic tumor volume predicts outcome in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012;83:1514–20.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Demirci U, Coskun U, Akdemir UO, Benekli M, Kapucu O, Ozkan S, et al. The nodal standard uptake value (SUV) as a prognostic factor in head and neck squamous cell cancer. Asian Pac J Cancer Prev. 2011;12:1817–20.

    PubMed  Google Scholar 

  95. Inokuchi H, Kodaira T, Tachibana H, Nakamura T, Tomita N, Nakahara R, et al. Clinical usefulness of [18F] fluoro-2-deoxy-D-glucose uptake in 178 head-and-neck cancer patients with nodal metastasis treated with definitive chemoradiotherapy: consideration of its prognostic value and ability to provide guidance for optimal selection of patients for planned neck dissection. Int J Radiat Oncol Biol Phys. 2011;79:747–55.

    Article  PubMed  Google Scholar 

  96. Kubicek GJ, Champ C, Fogh S, Wang F, Reddy E, Intenzo C, et al. FDG-PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol. 2010;16:19–25.

    Article  Google Scholar 

  97. Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, et al. Prognostic value of FDG PET imaging in patients with laryngeal cancer. PLoS One. 2014;9(5):e96999.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  98. Chan SC, Chang JT, Lin CY, Ng SH, Wang HM, Liao CT, et al. Clinical utility of 18F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification. Nucl Med Commun. 2011;32:989–96.

    Article  PubMed  Google Scholar 

  99. Paidpally V, Chirindel A, Lam S, Agrawal N, Quon H, Subramaniam RM. FDGPET/CT imaging biomarkers in head and neck squamous cell carcinoma. Imaging Med. 2012;4:633–47.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  100. Lim R, Eaton A, Lee NY, Setton J, Ohri N, Rao S, et al. 18F-FDG PET/CT metabolic tumor volume and total lesion glycolysis predict outcome in oropharyngeal squamous cell carcinoma. J Nucl Med. 2012;53:1506–13.

    Article  PubMed  CAS  Google Scholar 

  101. Park GC, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY. Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx. Ann Oncol. 2013;24:208–24.

    Article  PubMed  CAS  Google Scholar 

  102. Abd El-Hafez YG. Moustafa HM, Khalil HF, Liao CT, Yen TC. Total lesion glycolysis: a possible new prognostic parameter in oral cavity squamous cell carcinoma. Oral Oncol. 2013;49:261–8.

    Article  PubMed  CAS  Google Scholar 

  103. Chang KP, Tsang NM, Liao CT, Hsu CL, Chung MJ, Lo CW, et al. Prognostic significance of 18F-FDG PET parameters and plasma Epstein-Barr virus DNA load in patients with nasopharyngeal carcinoma. J Nucl Med. 2012;53:21–8.

    Article  PubMed  CAS  Google Scholar 

  104. Pak K, Cheon GJ, Nam HY, Kim SJ, Kang KW, Chung JK, et al. Prognostic value of metabolic tumor volume and total lesion glycolysis in head and neck cancer: a systematic review and meta-analysis. J Nucl Med. 2014;55:884–90.

    Article  PubMed  CAS  Google Scholar 

  105. Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, et al. Cystic lymph node metastasis in patients with head and neck cancer: an HPV-associated phenomenon. Head Neck. 2008;30:898–903.

    Article  PubMed  Google Scholar 

  106. Subramaniam RM, Alluri KC, Tahari AK, Aygun N, Quon H. PET/CT imaging and human papilloma virus-positive oropharyngeal squamous cell cancer: evolving clinical imaging paradigm. J Nucl Med. 2014;55:431–8.

    Article  PubMed  Google Scholar 

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Kitajima, K., Suenaga, Y. & Sugimura, K. Present and future role of FDG-PET/CT imaging in the management of head and neck carcinoma. Jpn J Radiol 33, 776–789 (2015). https://doi.org/10.1007/s11604-015-0495-1

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