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Interactions Between Pattern Formation and Domain Growth

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Abstract

In this paper we develop a theoretical framework for investigating pattern formation in biological systems for which the tissue on which the spatial pattern resides is growing at a rate which is itself regulated by the diffusible chemicals that establish the spatial pattern. We present numerical simulations for two cases of interest, namely exponential domain growth and chemically controlled growth. Our analysis reveals that for domains undergoing rapid exponential growth dilution effects associated with domain growth influence both the spatial patterns that emerge and the concentration of chemicals present in the domain. In the latter case, there is complex interplay between the effects of the chemicals on the domain size and the influence of the domain size on the formation of patterns. The nature of these interactions is revealed by a weakly nonlinear analysis of the full system. This yields a pair of nonlinear equations for the amplitude of the spatial pattern and the domain size. The domain is found to grow (or shrink) at a rate that depends quadratically on the pattern amplitude, the particular functional forms used to model the local tissue growth rate and the kinetics of the two diffusible species dictating the resulting behaviour.

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Authors and Affiliations

  1. Centre for Mathematical Medicine, School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK

    A. A. Neville, P. C. Matthews & H. M. Byrne

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  1. A. A. Neville
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  2. P. C. Matthews
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  3. H. M. Byrne
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Correspondence to H. M. Byrne.

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Neville, A.A., Matthews, P.C. & Byrne, H.M. Interactions Between Pattern Formation and Domain Growth. Bull. Math. Biol. 68, 1975–2003 (2006). https://doi.org/10.1007/s11538-006-9060-5

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