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RETRACTED ARTICLE: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice

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This article was retracted on 03 March 2020

This article has been updated

Abstract

Honokiol, a constituent of Magnolia obovata, has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotective effects of honokiol against cerebral ischemia. We recently reported that cerebral ischemic neuronal damage could be triggered by glucose intolerance that develops after the onset of ischemic stress (i.e., post-ischemic glucose intolerance). In addition, suppression of post-ischemic glucose intolerance significantly ameliorated ischemic neuronal damage. Here, we investigated the effects of honokiol on the development of post-ischemic glucose intolerance and neuronal damage. Mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h. The development of post-ischemic glucose intolerance on day 1 and neuronal damage on day 3 after MCAO were significantly reduced by intraperitoneal administration of honokiol (10 mg/kg) compared with the vehicle-treated group. Honokiol did not affect serum insulin or adiponectin levels. However, honokiol significantly decreased the expression of phosphoenolpyruvate carboxykinase and increased the expression of 5′-AMP-activated protein kinase (AMPK) on day 1 after MCAO, compared with the vehicle-treated MCAO group. The results of this study suggest that honokiol could prevent post-ischemic glucose intolerance in an AMPK-dependent manner, which may be involved in the neuroprotective effects of honokiol against cerebral ischemia.

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Change history

  • 03 March 2020

    This article [1] has been retracted at the request of the corresponding author because an Investigation Committee established by Kobe Gakuin University (Kobe, Japan) has found numerous discrepancies between the raw data and the data presented in Figs.��6b, d. Statistical analysis of the raw data showed no significant difference between conditions. Authors S. Harada, K. Nakamoto, W. Fujita-Hamabe, H.-H. Chen, M.-H. Chan, and S. Tokuyama agree with this retraction. Authors M. Kishimoto and M. Kobayashi could not be reached for comment about this retraction.

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Acknowledgments

Parts of this study were supported by grants-in-aid and by special coordination funds from grants-in-aid for Scientific Research (C) (22500683) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Hyogo, Japan

    Shinichi Harada, Maya Kishimoto, Mana Kobayashi, Kazuo Nakamoto, Wakako Fujita-Hamabe & Shogo Tokuyama

  2. Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan

    Hwei-Hsien Chen & Ming-Huan Chan

Authors
  1. Shinichi Harada
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  2. Maya Kishimoto
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  3. Mana Kobayashi
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  4. Kazuo Nakamoto
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  5. Wakako Fujita-Hamabe
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  6. Hwei-Hsien Chen
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  7. Ming-Huan Chan
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  8. Shogo Tokuyama
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Corresponding author

Correspondence to Shogo Tokuyama.

Additional information

This article has been retracted at the request of the corresponding author because an Investigation Committee established by Kobe Gakuin University (Kobe, Japan) has found numerous discrepancies between the raw data and the data presented in figures 6B and 6D. Statistical analysis of the raw data showed no significant difference between conditions. Authors S. Harada, K. Nakamoto, W. Fujita-Hamabe, H.-H. Chen, M.-H. Chan, and S. Tokuyama agree with this retraction. Authors M. Kishimoto and M. Kobayashi could not be reached for comment about this retraction.

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Harada, S., Kishimoto, M., Kobayashi, M. et al. RETRACTED ARTICLE: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice. J Nat Med 66, 591–599 (2012). https://doi.org/10.1007/s11418-011-0623-x

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  • DOI: https://doi.org/10.1007/s11418-011-0623-x

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