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Recombined sequences between the non-coding control regions of JC and BK viruses found in the urine of a renal transplantation patient

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Abstract

Kidney cells are the common host for JC virus (JCV) and BK virus (BKV). Reactivation of JCV and/or BKV in patients after organ transplantation, such as renal transplantation, may cause hemorrhagic cystitis and polyomavirus-associated nephropathy. Furthermore, JCV and BKV may be shed in the urine after reactivation in the kidney. Rearranged as well as archetypal non-coding control regions (NCCRs) of JCV and BKV have been frequently identified in human samples. In this study, three JC/BK recombined NCCR sequences were identified in the urine of a patient who had undergone renal transplantation. They were designated as JC–BK hybrids 1, 2, and 3. The three JC/BK recombinant NCCRs contain up-stream JCV as well as down-stream BKV sequences. Deletions of both JCV and BKV sequences were found in these recombined NCCRs. Recombination of DNA sequences between JCV and BKV may occur during co-infection due to the relatively high homology of the two viral genomes.

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References

  1. B.L. Padgett, D.L. Walker, G.M. ZuRhein, R.J. Eckroade, B.H. Dessel, Lancet 1(7712), 1257–1260 (1971)

    Article  PubMed  CAS  Google Scholar 

  2. S.D. Gardner, A.M. Field, D.V. Coleman, B. Hulme, Lancet 1(7712), 1253–1257 (1971)

    Article  PubMed  CAS  Google Scholar 

  3. W.A. Knowles, Adv. Exp. Med. Biol. 577, 19–45 (2006)

    Article  PubMed  CAS  Google Scholar 

  4. P.M. Chesters, J. Heritage, D.J. McCance, J. Infect. Dis. 147(4), 676–684 (1983)

    Article  PubMed  CAS  Google Scholar 

  5. J. Heritage, P.M. Chesters, D.J. McCance, J. Med. Virol. 8(2), 143–150 (1981)

    Article  PubMed  CAS  Google Scholar 

  6. J.R. Berger, A. Chauhan, D. Galey, A. Nath, J. Neurovirol. 7(4), 329–338 (2001)

    Article  PubMed  CAS  Google Scholar 

  7. E.O. Major, K. Amemiya, C.S. Tornatore, S.A. Houff, J.R. Berger, Clin. Microbiol. Rev. 5(1), 49–73 (1992)

    PubMed  CAS  Google Scholar 

  8. R.R. Arthur, K.V. Shah, S.J. Baust, G.W. Santos, R. Saral, N. Engl. J. Med. 315(4), 230–234 (1986)

    Article  PubMed  CAS  Google Scholar 

  9. G. Bogdanovic, P. Priftakis, G. Giraud, M. Kuzniar, R. Ferraldeschi, P. Kokhaei, H. Mellstedt, M. Remberger, P. Ljungman, J. Winiarski, T. Dalianis, J. Clin. Microbiol. 42(11), 5394–5396 (2004)

    Article  PubMed  CAS  Google Scholar 

  10. V. Nickeleit, H.K. Singh, M.J. Mihatsch, Adv. Exp. Med. Biol. 577, 190–200 (2006)

    Article  PubMed  CAS  Google Scholar 

  11. J. Tooze, Molecular Biology of Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1981)

    Google Scholar 

  12. Y. Yogo, T. Kitamura, C. Sugimoto, T. Ueki, Y. Aso, K. Hara, F. Taguchi, J. Virol. 64(6), 3139–3143 (1990)

    PubMed  CAS  Google Scholar 

  13. G.S. Ault, G.L. Stoner, J. Gen. Virol. 74(Pt 8), 1499–1507 (1993)

    Article  PubMed  CAS  Google Scholar 

  14. V. Pietropaolo, M. Videtta, D. Fioriti, M. Mischitelli, A. Arancio, N. Orsi, A.M. Degener, J. Neurovirol. 9(6), 603–611 (2003)

    PubMed  CAS  Google Scholar 

  15. B. Vaz, P. Cinque, M. Pickhardt, T. Weber, J. Neurovirol. 6(5), 398–409 (2000)

    Article  PubMed  CAS  Google Scholar 

  16. A. Egli, L. Infanti, A. Dumoulin, A. Buser, J. Samaridis, C. Stebler, R. Gosert, H.H. Hirsch, J. Infect. Dis. 199(6), 837–846 (2009)

    Article  PubMed  CAS  Google Scholar 

  17. R.B. Markowitz, W.S. Dynan, J. Virol. 62(9), 3388–3398 (1988)

    PubMed  CAS  Google Scholar 

  18. U. Moens, T. Johansen, J.I. Johnsen, O.M. Seternes, T. Traavik, Virus Genes 10(3), 261–275 (1995)

    Article  PubMed  CAS  Google Scholar 

  19. R. Rubinstein, N. Pare, E.H. Harley, J. Virol. 61(5), 1747–1750 (1987)

    PubMed  CAS  Google Scholar 

  20. P.N. Jensen, E.O. Major, J. Neurovirol. 7(4), 280–287 (2001)

    Article  PubMed  CAS  Google Scholar 

  21. C.H. Chen, M.C. Wen, M. Wang, J.D. Lian, M.J. Wu, C.H. Cheng, K.H. Shu, D. Chang, J. Med. Virol. 64(1), 82–88 (2001)

    Article  PubMed  CAS  Google Scholar 

  22. R. Cavallo, C. Costa, M. Bergallo, M. Messina, G. Mazzucco, G.P. Segoloni, Nephrol. Dial. Transplant. 22(4), 1275 (2007)

    Article  PubMed  Google Scholar 

  23. Y. Chen, P.M. Sharp, M. Fowkes, O. Kocher, J.T. Joseph, I.J. Koralnik, J. Gen. Virol. 85(Pt 9), 2651–2663 (2004)

    Article  PubMed  CAS  Google Scholar 

  24. R.M. Li, R.B. Mannon, D. Kleiner, M. Tsokos, M. Bynum, A.D. Kirk, J.B. Kopp, Transplantation 74(11), 1497–1504 (2002)

    Article  PubMed  Google Scholar 

  25. W.A. Knowles, P. Pipkin, N. Andrews, A. Vyse, P. Minor, D.W. Brown, E. Miller, J. Med. Virol. 71(1), 115–123 (2003)

    Article  PubMed  Google Scholar 

  26. S. Eash, K. Manley, M. Gasparovic, W. Querbes, W.J. Atwood, Cell. Mol. Life Sci. CMLS 63(7–8), 865–876 (2006)

    Article  CAS  Google Scholar 

  27. C. Polo, J.L. Perez, A. Mielnichuck, C.G. Fedele, J. Niubo, A. Tenorio, Clinical microbiology and infection. Euro. Soc. Clin. Microbiol. Infect. Dis. 10(7), 640–644 (2004)

    Article  CAS  Google Scholar 

  28. P. Randhawa, J. Uhrmacher, W. Pasculle, A. Vats, R. Shapiro, B. Eghtsead, K. Weck, J. Med. Virol. 77(2), 238–243 (2005)

    Article  PubMed  Google Scholar 

  29. A. Kazory, D. Ducloux, J.M. Chalopin, R. Angonin, B. Fontaniere, H. Moret, Transplantation 76(11), 1653–1655 (2003)

    Article  PubMed  Google Scholar 

  30. M.C. Wen, C.L. Wang, M. Wang, C.H. Cheng, M.J. Wu, C.H. Chen, K.H. Shu, D. Chang, J. Med. Virol. 72(4), 675–678 (2004)

    Article  PubMed  Google Scholar 

  31. K. Dorries, V. ter Meulen, J. Med. Virol. 11(4), 307–317 (1983)

    Article  PubMed  CAS  Google Scholar 

  32. C.B. Drachenberg, H.H. Hirsch, E. Ramos, J.C. Papadimitriou, Hum. Pathol. 36(12), 1245–1255 (2005)

    Article  PubMed  CAS  Google Scholar 

  33. C.B. Drachenberg, H.H. Hirsch, J.C. Papadimitriou, R. Gosert, R.K. Wali, R. Munivenkatappa, J. Nogueira, C.B. Cangro, A. Haririan, S. Mendley, E. Ramos, Transplantation 84(3), 323–330 (2007)

    Article  PubMed  Google Scholar 

  34. R. Robles-Sikisaka, R. Rivera, H.H. Nollens, J. St Leger, W.N. Durden, M. Stolen, J. Burchell, J.F. Wellehan Jr, Virology 427(2), 189–197 (2012)

    Article  PubMed  CAS  Google Scholar 

  35. I.E. Andernach, P. Jutavijittum, B. Samountry, A. Yousukh, T. Thammavong, J.M. Hubschen, C.P. Muller, PLoS One 7(2), e30245 (2012)

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank Dr. Michael WY Chan from the National Chung Cheng University for his critical reading and English editing. This work was supported by research grants from the National Science Council, NSC99-2321-B-194-001 and Chung Shan Medical University Hospital, CSH-2009-A-009, Taiwan, ROC.

Author information

Authors and Affiliations

  1. Clinical Research Center, Chung Shan Medical University Hospital, Taichung, Taiwan

    Yu-Ching Liaw & Meilin Wang

  2. Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    Cheng-Hsu Chen & Kuo-Hsiung Shu

  3. Department of Medical Research, Chiayi Christian Hospital, Chiayi, Taiwan

    Chiung-Yao Fang, Cheng-Huang Shen & Mien-Chun Lin

  4. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Wei-Chih Ou & Pei-Lain Chen

  5. Institute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan

    Deching Chang

  6. Department of Microbiology and Immunology, Chung Shan Medical University, 110, Section 1, Jianguo North Road, Taichung, 40201, Taiwan

    Meilin Wang

  7. Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan

    Meilin Wang

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  1. Yu-Ching Liaw
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  2. Cheng-Hsu Chen
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Correspondence to Meilin Wang.

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Yu-Ching Liaw and Cheng-Hsu Chen contributed equally to this work.

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Liaw, YC., Chen, CH., Shu, KH. et al. Recombined sequences between the non-coding control regions of JC and BK viruses found in the urine of a renal transplantation patient. Virus Genes 45, 581–584 (2012). https://doi.org/10.1007/s11262-012-0815-9

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  • DOI: https://doi.org/10.1007/s11262-012-0815-9

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