Abstract
Two new V(IV) complexes, [VO(Naph–trp)(phen)]·CH3OH (1) and [VO(o-Van–trp)(phen)]·CH3OH·H2O (2) (Naph–Trp = Schiff base derived from 2-hydroxy-1-naphthaldehyde and l-tryptophan, o-Van–trp = Schiff base derived from o-vanillin and l-tryptophan, phen = 1,10-phenanthroline), have been synthesized and characterized by physicochemical methods. The V(IV) atoms in both complexes are six-coordinated in a distorted octahedral environment. In the crystals of complex 1, the C–H···π and π–π stacking interactions form a 1D chain structure, whereas for complex 2, hydrogen bonds connect the molecular units into a 2D plane structure. The DNA binding properties and cleavage efficiencies of the complexes have been investigated by spectroscopic methods, viscosity measurements and agarose gel electrophoresis. The results suggest that both complexes can bind to CT-DNA in an intercalative mode and can also cleave pBR322 DNA.
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Hegg EL, Burstyn JN (1998) Coord Chem Rev 173:133
Zhang QL, Liu JG, Chao H, Xue GQ, Ji LN (2001) J Inorg Biochem 83:49
Jin L, Yang P (1997) J Inorg Biochem 68:79
Urathamakul T, Beck JL, Sheil MM, Aldrich-Wright JR, Ralph SF (2004) J Chem Soc Dalton Trans 17:2683
Gupta SK, Hitchcock PB, Kushwah YS, Argal GS (2007) Inorg Chim Acta 360:2145
Kumar RS, Sasikala K, Arunachalam S (2008) J Inorg Biochem 102:234
Poucheret P, Verma S, Grynpa SMD (1998) Mol Cell Biochem 188:73
Tsiani E, Fantus IG (1997) Trends Endocrinol Metab 8:51
Thompson KH, Orvig C (2006) J Inorg Biochem 100:1925
Sakurai H, Kojima Y, Yoshikawa Y, Kawabe K, Yasui H (2002) Coord Chem Rev 226:187
Domingo JL, Gomez ML, Corbella J (1991) Toxicology 61:279
Nath M, Pokharia S, Yadav R (2001) Coord Chem Rev 215:99
Sasmal PK, Patra AK, Chakravarty AR (2008) J Inorg Biochem 102:1463
Kwong DWJ, Chan OY, Shek LK, Wong RNS (2005) J Inorg Biochem 99:2062
Li LZ, Guo ZH, Zhang QF, Xu T, Wang DQ (2010) Inorg Chem Commun 13:1166
Xu T, Li LZ, Zhou SF, Guo GF, Niu MJ (2005) J Chem Crystallogr 35:263
Bian L, Li LZ, Zhang QF, Liu HL, Wang DQ (2011) Acta Chim Sinica 69:1661
Sheldrick GM (1977) SHELXL-97, program for the solution and the refinement of crystal structures. University of Gottingen, Germany
Marmur J (1961) J Mol Biol 3:208
Reichmann ME, Rice SA, Thomas CA, Doty P (1954) J Am Chem Soc 76:3047
Kawabe K, Tadokoro M, Hirotsu K, Yanagihara N, Kojima Y (2000) Inorg Chem Acta 305:172
Tong ML, Lee HK, Chen XM, Huang RB, Mak TCW (1999) J Chem Soc Dalton Trans 3657
Janiak C (2000) J Chem Soc Dalton Trans 3885
Wolfe A, Shimer GH, Meehan JT (1987) Biochemistry 26:6392
Strothkamp KG, Strothkamp RE (1994) J Chem Educ 71:77
Lakowicz JR, Weber G (1973) Biochemistry 12:4161
Uma V, Kanthimathi M, Weyhermuller T, Nair BU (2005) J Inorg Biochem 99:2299
Barton JK, Raphael AL (1984) J Am Chem Soc 106:2466
Acknowledgments
This project was supported by the Natural Science Foundation of Shandong Province of China (No.Y2004B02) and the Special-purpose Construction Project Foundation for “Taishan Scholar” of Shandong Province.
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Bian, L., Li, L., Zhang, Q. et al. Synthesis, crystal structures, DNA binding and cleavage studies of two oxovanadium(IV) complexes of 1,10-phenanthroline and Schiff bases derived from tryptophan. Transition Met Chem 37, 783–790 (2012). https://doi.org/10.1007/s11243-012-9653-9
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DOI: https://doi.org/10.1007/s11243-012-9653-9