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A near-infrared fluorescent probe for rapid and selective detection of hydrosulfide and imaging in live cells

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Abstract

A heptamethine cyanine-based near-infrared (NIR) fluorescent probe Cy-1 for hydrosulfide detection was developed, with the response mechanism based on nucleophilic substitution of acryloyl moiety by HS−. Upon addition of NaHS, Cy-1 displayed a rapid fluorescence quenching (excited at 700 nm) and a quick fluorescence enhancement (excited at 544 nm) as well as obvious changes in absorption spectra and color. The response was fast within tens of seconds and could be observed by naked eyes. By contrasting Cy-1 with the reported probe CyAC, the superiority of Cy-1 in selectivity over Cys was demonstrated. Besides, it also exhibited excellent selectivity and sensitivity to HS− over various anions (0.33-μM detection limit). Additionally, this probe was successfully applied in fetal bovine serum samples and imaging of hydrosulfide in living cells.

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Acknowledgements

We are grateful for the financial support from the National Natural Science Foundation of China (21576194).

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China

    Yichen Jiang, Di Jin, Yang Li, Xilong Yan & Ligong Chen

  2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, People’s Republic of China

    Yichen Jiang, Di Jin, Yang Li, Xilong Yan & Ligong Chen

  3. Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin, People’s Republic of China

    Yang Li, Xilong Yan & Ligong Chen

Authors
  1. Yichen Jiang
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  2. Di Jin
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  3. Yang Li
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  4. Xilong Yan
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  5. Ligong Chen
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Corresponding authors

Correspondence to Xilong Yan or Ligong Chen.

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Jiang, Y., Jin, D., Li, Y. et al. A near-infrared fluorescent probe for rapid and selective detection of hydrosulfide and imaging in live cells. Res Chem Intermed 43, 2945–2957 (2017). https://doi.org/10.1007/s11164-016-2805-3

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  • DOI: https://doi.org/10.1007/s11164-016-2805-3

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