Abstract
An extremely simple, economical and environmentally benign protocol has been described for one-pot synthesis of 1-oxo-hexahydroxanthenes by pseudo three-component condensation between salicylaldehydes and dimedone, cyclohexane-1,3-dione or 5-methyl cyclohexane-1,3-dione using diethylamine as the catalyst. Based upon the mechanism of the reaction, the protocol has been extended towards the synthesis of tetraketones and bis-coumarins.
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Acknowledgements
Authors KSP and UVD are thankful to the University Grants Commission (UGC), New Delhi for financial assistance [F. 43-221-2014/SR]. We are also grateful to the Department of Science & Technology (DST), New Delhi for financial assistance to the Department of Chemistry, Shivaji University Kolhapur under the DST–FIST program.
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Kupwade, R.V., Pandit, K.S., Desai, U.V. et al. Diethylamine-catalyzed environmentally benign synthesis of 1-oxo-hexahydroxanthenes and bis-coumarins at ambient temperature. Res Chem Intermed 42, 6313–6325 (2016). https://doi.org/10.1007/s11164-016-2464-4
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DOI: https://doi.org/10.1007/s11164-016-2464-4