Abstract
A catalyst-free greener protocol for the most effective one-pot synthesis of 2,6-diamino-4-aryl-1-propyl/cyclohexyl-1,4-dihydropyridine-3,5-dicarbonitrile derivatives has been developed using a simple three-component reaction of structurally diverse aldehydes, malononitrile and n-propylamine/cyclohexylamine at an ambient temperature. The formation of 1,4-dihydropyridines could be achieved in aqueous methanol in a single synthetic process involving no chromatography. The newly synthesized highly functionalized 1,4-DHPs have been screened for their in vitro antioxidant activity using the DPPH radical scavenging technique and the results were good in comparison with a standard drug.
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Acknowledgments
R.R. gratefully acknowledges the financial support from the DST-Inspire Fellowship (No: DST/INSPIRE Fellowship/2012/690) New Delhi, India. We thank Dr. V. Sujatha for providing UV–Vis spectral facilities.
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Ramesh, R., Maheswari, S., Murugesan, S. et al. Catalyst-free one-pot synthesis and antioxidant evaluation of highly functionalized novel 1,4-dihydropyridine derivatives. Res Chem Intermed 41, 8233–8243 (2015). https://doi.org/10.1007/s11164-014-1887-z
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DOI: https://doi.org/10.1007/s11164-014-1887-z