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An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction

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Abstract

An efficient and convenient method for the preparation of 3-aryl-2,3-dihydr-othiophene-2-carboxamide derivatives in absolute ethyl alcohol by thiazolidine-2,4-dione, aromatic aldehyde, malononitrile and n-butylamine without using any other catalysts was reported. This methodology has the advantages of high yields, simple work-up procedure and mild reaction conditions.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (NSFC) (21172188), Foundation of Xuzhou Normal University (10XLS02) and Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, People’s Republic of China

    Da Teng, Sheng Xia, Shimin Tao, Lijiu Gao, Youjian Feng & Liangce Rong

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  1. Da Teng
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  2. Sheng Xia
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  3. Shimin Tao
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  4. Lijiu Gao
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  5. Youjian Feng
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  6. Liangce Rong
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Correspondence to Liangce Rong.

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Teng, D., Xia, S., Tao, S. et al. An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction. Res Chem Intermed 39, 561–568 (2013). https://doi.org/10.1007/s11164-012-0579-9

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  • DOI: https://doi.org/10.1007/s11164-012-0579-9

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