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Male fertility and skin diseases

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Abstract

Male fertility can be affected by a variety of organs diseases, including the skin. Several genodermatoses affect the skin and several other organs including the male reproductive system, commonly in the form of cryptorchidism and hypogonadism. The most relevant syndromes are associated with dyschromias, such as deSanctis-Cacchione, poikiloderma congenital, LEOPARD, and H syndrome; others with ichthyosis, such as Rud, and trichothiodystrophy; or a group of unrelated genodermatoses, such as ablepharon macrostomia, Coffin-Siris, Gorlin-Goltz, and Werner. Acquired skin diseases may also affect male fertility usually in the form of orchitis or epididymal obstruction or androgen antagonists. These include infections (leprosy and HIV), autoimmune (erythema nodosum leprosum), granulomatous (sarcoidosis, Langerhans cell histiocytosis), nutritional deficiency (zinc), and malignancy. Several therapeutics of skin diseases are notorious for their effects on male fertility, most notably are the cytotoxic drugs (methotrexate), irradiation, and antiandrogens (spironolactone, finasteride). Although the prevalence of these skin diseases is low, the associated male infertility represents a challenge due to the difficulty of its management. Clinical management of the skin diseases should include consideration of their effects not only on the diseases but also on the male reproductive system.

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References

  1. Koehn FM, Ring J, Schill WB. Dermatologic aspects of male hypogonadism. Hautarzt. 2000;51:223–30.

    Article  Google Scholar 

  2. Wirth JJ, Mijal RS. Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med. 2010;56:147–67.

    Article  CAS  PubMed  Google Scholar 

  3. Sweeney MF, Hasan N, Soto AM, Sonnenschein C. Environmental endocrine disruptors: effects on the human male reproductive system. Rev Endocr Metab Disord. 2015;16:341–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Woolf PD, Hamill RW, McDonald JV, Lee LA, Kelly M. Transient hypogonadotropic hypogonadism caused by critical illness. J Clin Endocrinol Metab. 1985;60:444–50.

    Article  CAS  PubMed  Google Scholar 

  5. Semple CG, Robertson WR, Mitchell R, Gordon D, Gray CE, Beastall GH, et al. Mechanisms leading to hypogonadism in men with burns injuries. Br Med J. 1987;295:403–7.

    Article  CAS  Google Scholar 

  6. Dong Q, Hawker F, McWilliam D, Bangah M, Burger H, Handelsman DJ. Circulating immunoreactive inhibin and testosterone levels in men with critical illness. Clin Endocrinol (Oxf). 1992;36:399–404.

    Article  CAS  Google Scholar 

  7. Eisenberg ML, Li S, Behr B, Pera RR, Cullen MR. Relationship between semen production and medical comorbidity. Fertil Steril. 2015;103:66–71.

    Article  PubMed  Google Scholar 

  8. Kandeel FR, Swerdloff RS. Role of temperature in regulation of spermatogenesis and the use of heating as a method of contraception. Fertil Steril. 1988;49:1–23.

    Article  CAS  PubMed  Google Scholar 

  9. Handelsman DJ, Staraj S. Testicular size: the effects of aging, malnutrition, and illness. J Androl. 1985;6:144–51.

    Article  CAS  PubMed  Google Scholar 

  10. Li TC, Hindle JE. Adverse local reaction to intramuscular injections of urinary-derived gonadotrophins. Hum Reprod. 1993;8:1835–6.

    CAS  PubMed  Google Scholar 

  11. Matorras R, Perez C, Corcostegui B, Pijoan JI, Ramon O, Delgado P, et al. Treatment of the male with follicle-stimulating hormone in intrauterine insemination with husband’s spermatozoa: a randomized study. Hum Reprod. 1997;12:24–8.

    Article  CAS  PubMed  Google Scholar 

  12. Jordan Jr WP, Atkinson LE, Lai C. Comparison of the skin irritation potential of two testosterone transdermal systems: an investigational system and a marketed product. Clin Ther. 1998;20:80–7.

    Article  CAS  PubMed  Google Scholar 

  13. Marshall JD, Beck S, Maffei P, Naggert JK. Alstrom syndrome. Eur J Hum Genet. 2007;15:1193–202.

    Article  CAS  PubMed  Google Scholar 

  14. Berlin CI. Congenital generalized melanoleucoderma associated with hypodontia, hypotrichosis, stunted growth and mental retardation occurring in two brothers and two sisters. Dermatologica. 1961;123:227–43.

    Article  CAS  PubMed  Google Scholar 

  15. Legius E, Daenen W, Vandenbergh V, Verbeeck G, Bex M, Fryns JP. Syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex). Genet Couns. 1998;9:287–90.

    CAS  PubMed  Google Scholar 

  16. Koch CA, Bornstein SR, Chrousos GP, Stratakis CA. Primäre pigmentierte noduläre adrenokortikale Dysplasie (PPNAD) im Rahmen des Carney-Komplexes als Ursache eines Cushing-Syndroms. Med Klin (Munich). 2000;95:224–30.

    Article  CAS  Google Scholar 

  17. Stratakis CA. Carney complex: a familial lentiginosis predisposing to a variety of tumors. Rev Endocr Metab Disord. 2016. in press.

  18. Wieacker P, Stratakis CA, Horvath A, Klose S, Nickel I, Buhtz P, et al. Male infertility as a component of Carney complex. Andrologia. 2007;39:196–7.

    Article  CAS  PubMed  Google Scholar 

  19. Kirschner LS, Sandrini F, Monbo J, Lin J-P, Carney JA, Stratakis CA. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum Mol Genet. 2000;9:3037–46.

    Article  CAS  PubMed  Google Scholar 

  20. Sharma ST, Nieman LK, Feelders RA. Cushing’s syndrome: epidemiology and developments in disease management. Clin Epidemiol. 2015;7:281–93.

    PubMed  PubMed Central  Google Scholar 

  21. Reed WB, Sugarman G, Mathis RA. DeSanctis-Cacchione syndrome. Arch Dermatol. 1977;113:1561.

    Article  CAS  PubMed  Google Scholar 

  22. Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum: cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123:241–50.

    Article  CAS  PubMed  Google Scholar 

  23. Colella S, Nardo T, Botta E, Lehmann AR, Stefanini M. Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-Cacchione variant of xeroderma pigmentosum. Hum Mol Genet. 2000;9:1171–5.

    Article  CAS  PubMed  Google Scholar 

  24. Davidson HR, Connor JM. Dyskeratosis congenita. J Med Genet. 1988;25:843–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Joenje H, Oostra AB, Wijker M, di Summa FM, van Berkel CG, Rooimans MA, et al. Evidence for at least eight Fanconi anemia genes. Am J Hum Genet. 1997;61:940–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. De Kerviler E, Guermazi A, Zagdanski AM, Gluckman E, Frija J. The clinical and radiological features of Fanconi’s anemia. Clin Radiol. 2000;55:340–5.

    Article  PubMed  Google Scholar 

  27. Fryns JP, Gevers D. Goeminne syndrome (OMIM 314300): another male patient 30 years later. Genet Couns. 2003;14:109–11.

    CAS  PubMed  Google Scholar 

  28. Morgan NV, Morris MR, Cangul H, Gleeson D, Straatman-Iwanowska A, Davies N, et al. Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease. PLoS Genet. 2010;6:e1000833.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Molho-Pessach V, Agha Z, Aamar S, Glaser B, Doviner V, Hiller N, et al. The H syndrome: a genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin with systemic manifestations. J Am Acad Dermatol. 2008;59:79–85.

    Article  PubMed  Google Scholar 

  30. Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, et al. Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med. 2008;358:592–604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Coppin BD, Temple IK. Multiple lentigines syndrome (LEOPARD syndrome or progressive cardiomyopathic lentiginosis). J Med Genet. 1997;34:582–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Verhagen MMM, Abdo WF, Willemsen MAAP, Hogervorst FBL, Smeets DFCM, Hiel JAP, et al. Clinical spectrum of ataxia-telangiectasia in adulthood. Neurology. 2009;73:430–7.

    Article  CAS  PubMed  Google Scholar 

  33. Dumitrescu CE, Collins MT. McCune-Albright syndrome. Orphanet J Rare Dis. 2008;3:12.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Boyce AM, Chong WH, Shawker TH, Pinto PA, Linehan WM, Bhattacharryya N, et al. Characterization and management of testicular pathology in McCune-Albright syndrome. J Clin Endocrinol Metab. 2012;97:E1782–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Prader A, Labhart A, Willi H. Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach Myatonieartigem Zustand im Neugeborenenalter. Schweiz Med Wschr. 1956;86:1260–1.

    Google Scholar 

  36. Bray GA, Dahms WT, Swerdloff RS, Fiser RH, Atkinson RL, Carrel RE. The Prader-Willi syndrome: a study of 40 patients and a review of the literature. Medicine. 1983;62:59–80.

    Article  CAS  PubMed  Google Scholar 

  37. Hamilton Jr CR, Scully RE, Kliman B. Hypogonadotropism in Prader-Willi syndrome: induction of puberty and spermatogenesis by clomiphene citrate. Am J Med. 1972;52:322–9.

    Article  PubMed  Google Scholar 

  38. Lindor NM, Furuichi Y, Kiato S, et al. Rothman-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom’s and Werner’s syndromes. Am J Med Genet. 2000;90:223.

    Article  CAS  PubMed  Google Scholar 

  39. Venos EM, Collins M, Jane WD. Rothmund-Thomson syndrome: review of the world literature. J Am Acad Dermatol. 1992;27:750.

    Article  Google Scholar 

  40. Starr DG, McClure JP, Connor JM. Non-dermatological complications and genetic aspects of the Rothmund-Thomson syndrome. Clin Genet. 1985;27:102–4.

    Article  CAS  PubMed  Google Scholar 

  41. Adachi M, Muroya K, Asakura Y, Kurosawa K, Nishimura G, Narumi S, et al. Ruvalcaba syndrome revisited (letter). Am J Med Genet. 2010;152A:1854–7.

    Article  PubMed  Google Scholar 

  42. Blyth M, Maloney V, Beal S, Collinson M, Huang S, Crolla J, et al. Pallister-Killian syndrome: a study of 22 British patients. J Med Genet. 2015;52:454–64.

    Article  CAS  PubMed  Google Scholar 

  43. Suryawanshi A, Middleton T, Ganda K. An unusual presentation of X-linked adrenoleukodystrophy. Endocrinol Diabetes Metab Case Rep. 2015;2015:150098.

    PubMed  PubMed Central  Google Scholar 

  44. Marxmiller J, Trenkle I, Ashwal S. Rud syndrome revisited: ichthyosis, mental retardation, epilepsy and hypogonadism. Dev Med Child Neurol. 1985;27:335–43.

    Article  CAS  PubMed  Google Scholar 

  45. Stoll C, Eyer D. A syndrome of congenital ichthyosis, hypogonadism, small stature, facial dysmorphism, scoliosis and myogenic dystrophy. Ann Genet. 1999;42:45–50.

    CAS  PubMed  Google Scholar 

  46. Munke M, Kruse K, Goos M, Ropers HH, Tolksdorf M. Genetic heterogeneity of the ichthyosis, hypogonadism, mental retardation, and epilepsy syndrome: clinical and biochemical investigations on two patients with Rud syndrome and review of the literature. Eur J Pediatr. 1983;141:8–13.

    Article  CAS  PubMed  Google Scholar 

  47. Jorizzo JL, Crounse RG, Wheeler Jr CE. Lamellar ichthyosis, dwarfism, mental retardation, and hair shaft anomalies. J Am Acad Dermatol. 1980;2:309.

    Article  CAS  PubMed  Google Scholar 

  48. Faghri S, Tamura D, Kraemer KH, DiGiovanna JJ. Trichothiodystrophy: a systematic review of 112 published cases characterizes a wide spectrum of clinical manifestations. J Med Genet. 2008;45:609–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Hashimoto S, Egly JM. Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH. Hum Mol Genet. 2009;18:R224–30.

    Article  CAS  PubMed  Google Scholar 

  50. Hersh JH, Klein LR, Joyce MR, Hordinsky MK, Tsai MY, Paller A, et al. Trichothiodystrophy and associated anomalies: a variant of SIBIDS or new symptom complex? Pediatr Dermatol. 1993;10:117–22.

    Article  CAS  PubMed  Google Scholar 

  51. Stevens CA, Sargent LA. Ablepharon-macrostomia syndrome. Am J Med Genet. 2002;107:30–7.

    Article  PubMed  Google Scholar 

  52. Boyle MI, Jespersgaard C, Brondum-Nielsen K, Bisgaard A-M, Tumer Z. Cornelia de Lange syndrome. Clin Genet. 2015;88:1–12.

    Article  CAS  PubMed  Google Scholar 

  53. Vergano SS, Deardorff MA. Clinical features, diagnostic criteria, and management of Coffin-Siris syndrome. Am J Med Genet. 2014;166C:252–6.

    Article  PubMed  CAS  Google Scholar 

  54. Mohrenschlager M, Beham A, Abeck D, Ring J. Atopic eczema in monozygotic twins with Dubowitz syndrome (letter). Br J Dermatol. 1998;138:1091–2.

    Article  CAS  PubMed  Google Scholar 

  55. Pras E, Aksentijevich I, Levy E, Gruberg L, Prosen L, Dean M, et al. The gene causing familial Mediterranean fever maps to the short arm of chromosome 16 in Druze and Moslem Arab families. Hum Genet. 1994;94:576–7.

    Article  CAS  PubMed  Google Scholar 

  56. Mijatovic V, Hompes PG, Wouters MG. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol. 2003;108:171–6.

    Article  PubMed  Google Scholar 

  57. Freire-Maia N. A newly recognized genetic syndrome of tetramelic deficiencies, ectodermal dysplasia, deformed ears, and other abnormalities. Am J Hum Genet. 1970;22:370–7.

    CAS  PubMed  Google Scholar 

  58. Gordon H, Davies D, Berman MM. Camptodactyly, cleft palate and club foot: syndrome showing the autosomal-dominant pattern of inheritance. J Med Genet. 1969;6:266–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Kimonis VE, Singh KE, Zhong R, Pastakia B, DiGiovanna JJ, Bale SJ. Clinical and radiological features in young individuals with nevoid basal cell carcinoma syndrome. Genet Med. 2013;15:79–83.

    Article  PubMed  Google Scholar 

  60. Cohen Jr MM. Hallermann-Streiff syndrome: a review. Am J Med Genet. 1991;41:488–99.

    Article  PubMed  Google Scholar 

  61. Tran TA, Koné-Paut I, Marie I, Ninet J, Cuisset L, Meinzer U. Muckle-Wells syndrome and male hypofertility: a case series. Semin Arthritis Rheum. 2012;42:327–31.

    Article  PubMed  Google Scholar 

  62. Romano AA, Allanson JE, Dahlgren J, et al. Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics. 2010;126:746–59.

    Article  PubMed  Google Scholar 

  63. Noonan JA, Raaijmakers R, Hall BD. Adult height in Noonan syndrome. Am J Med Genet. 2003;123A:68–71.

    Article  PubMed  Google Scholar 

  64. Woodhouse CRJ, Ransley PG, Innes-Williams D. Prune belly syndrome—report of 47 cases. Arch Dis Child. 1982;57:856–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Tramonte JJ, Burns TM. Myotonic dystrophy. Arch Neurol. 2005;62:1316–9.

    Article  PubMed  Google Scholar 

  66. Sagel J, Distiller LA, Morley JE, Isaacs H, Kay G, van der Walt A. Myotonia dystrophica: studies on gonadal function using luteinising-releasing-hormone (LRH). J Clin Endocrinol Metab. 1975;40:1110.

    Article  CAS  PubMed  Google Scholar 

  67. Thakker RV, Newey PJ, Walls GV, Bilezikian J, Dralle H, Ebeling PR, et al. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J Clin Endocrinol Metab. 2012;97:2990–3011.

    Article  CAS  PubMed  Google Scholar 

  68. Goto M, Ishikawa Y, Sugimoto M, Furuichi Y. Werner syndrome: a changing pattern of clinical manifestations in Japan (1917∼2008). Biosci Trends. 2013;7:13–22.

    CAS  PubMed  Google Scholar 

  69. Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner’s syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine. 1966;45:177–222.

    Article  CAS  PubMed  Google Scholar 

  70. Tritsch H, Lischka G. Werner’s Syndrom, kombiniert mit Pseudo-Klinefelter syndrom. Hautarzt. 1968;19:547.

    CAS  PubMed  Google Scholar 

  71. Akhtar M, Ali MA, Mackey DM. Lepromatous leprosy presenting as orchitis. Am J Clin Pathol. 1980;73:72–5.

    Article  Google Scholar 

  72. Saporta L, Yuksel A. Androgenic status in patients with lepromatous leprosy. Br J Urol. 1994;74:221–4.

    Article  CAS  PubMed  Google Scholar 

  73. Ghorpade A, Ramanam C. Primary penile tuberculoid leprosy. Indian J Lepr. 2000;72:499–500.

    CAS  PubMed  Google Scholar 

  74. Parikh DA, Parikh AC, Ganapati R. Penile and scrotal lesions in leprosy: case reports. Lepr Rev. 1989;60:303–5.

    CAS  PubMed  Google Scholar 

  75. World Health Organization. WHO expert committee on leprosy. Sixth report. In: Tech Rep Ser, vol. 768. Genera: WHO; 1988.

    Google Scholar 

  76. Cheng L, Bostwick DG, editors. Essentials of anatomic pathology. Totowa: Humana Press; 2002.

    Google Scholar 

  77. Brookings C, Goldmeier D, Sadeghi-Nejad H. Sexually transmitted infections and sexual function in relation to male fertility. Korean J Urol. 2013;54:149–56.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Gorse JG, Belshe RB. Male genital tuberculosis: a review of the literature with instructive case reports. Rev Infect Dis. 1985;7:511–24.

    Article  CAS  PubMed  Google Scholar 

  79. Lewis EL. Tuberculosis of the penis: a report of 5 cases and complete review of the literature. J Urol. 1946;56:737–45.

    CAS  PubMed  Google Scholar 

  80. Richens J. Genital manifestations of tropical diseases. Sex Transm Infect. 2004;80:12–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. De Paepe ME, Waxman M. Testicular atrophy in AIDS: a study of 57 autopsy cases. Hum Pathol. 1989;20:210–4.

    Article  PubMed  Google Scholar 

  82. Villette JM, Bourin P, Doinel C, Mansour I, Fiet J, Boudou P, et al. Circadian variations in plasma levels of hypophyseal, adrenocortical and testicular hormones in men infected with human immunodeficiency virus. J Clin Endocrinol Metab. 1990;70:572–7.

    Article  CAS  PubMed  Google Scholar 

  83. Crittenden JA, Handelsman DJ, Stewart GJ. Semen analysis in human immunodeficiency virus infection. Fertil Steril. 1992;57:1294–9.

    Article  CAS  PubMed  Google Scholar 

  84. Nicopoulos JD, Almeida PA, Ramsay JW, Gilling-Smith C. The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing. Hum Reprod. 2004;19:2289–97.

    Article  Google Scholar 

  85. Grunert E, Nyfors A, Hansen KB. Studies on human semen in topical corticosteroid-treated and in methotrexate-treated psoriatics. Dermatologica. 1977;154:78–84.

    Article  Google Scholar 

  86. Sussman A, Leonard JM. Psoriasis, methotrexate, and oligospermia. Arch Dermatol. 1980;116:215–7.

    Article  CAS  PubMed  Google Scholar 

  87. Sahana PK, Sarma N, Sengupta N, Somani PS. A florid case of iatrogenic Cushing’s syndrome induced by topical steroid with osteoporosis and hypogonadism. Indian J Dermatol. 2015;60:420.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Hendry WF, Munro DD. “Wash leather scrotum” (scrotal dermatitis): a treatable cause of male infertility. Fertil Steril. 1990;53:379–81.

    Article  CAS  PubMed  Google Scholar 

  89. Van Ahlen H, Hertle L. Disorders of sperm deposition. In: Nieschlag E, Behre HM, editors. Andrology. Berlin: Springer-Verlag; 1997. p. 176.

    Google Scholar 

  90. Hayes FJ, Seminara SB, Crowley Jr WF. Hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am. 1998;27:739–63.

    Article  CAS  PubMed  Google Scholar 

  91. Kovac JR, Flood D, Mullen JB, Fischer MA. Diagnosis and treatment of azoospermia resulting from testicular sarcoidosis. J Androl. 2012;33:162–6.

    Article  CAS  PubMed  Google Scholar 

  92. Porter N, Beynon HL, Randeva HS. Endocrine and reproductive manifestations of sarcoidosis. Q J Med. 2003;96:553–61.

    Article  CAS  Google Scholar 

  93. Arico M, Girschikofsky M, Genereau T, Klersy C, McClain K, Grois N, et al. Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. Eur J Cancer. 2003;39:2341–8.

    Article  CAS  PubMed  Google Scholar 

  94. García Gallo MS, Martínez MP, Abalovich MS, Gutiérrez S, Guitelman MA. Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults. Pituitary. 2010;13:298–303.

    Article  PubMed  CAS  Google Scholar 

  95. Khamseh ME, Mollanai S, Hashemi F, Rezaizadeh A, Azizi F. Erdheim-Chester syndrome, presenting as hypogonadotropic hypogonadism and diabetes insipidus. J Endocrinol Invest. 2002;25:727–9.

    Article  CAS  PubMed  Google Scholar 

  96. Sheu SY, Wenzel RR, Kersting C, Merten R, Otterbach F, Schmid KW. Erdheim-Chester disease: case report with multisystemic manifestations including testes, thyroid, and lymph nodes, and a review of literature. J Clin Pathol. 2004;57:1225–8.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Muhammad SS, Epstein JI. Testicular vasculitis: implications of systemic disease. Hum Pathol. 1987;19:186–9.

    Google Scholar 

  98. Jequier AM. Obstruction of the excurrent duct system of the testes. In: Jaquier AM, editor. Male infertility, a clinical guide. 2nd ed. New York: Cambridge University press; 2011. p. 79.

    Chapter  Google Scholar 

  99. Kumar B, Dogra S, Kaur I. Epidemiological characteristics of leprosy reactions: 15 years experience from north India. Int J Lepr Other Mycobact Dis. 2004;72:125–33.

    Article  PubMed  Google Scholar 

  100. Silva CA, Brunner HI. Gonadal functioning and preservation of reproductive fitness with juvenile systemic lupus erythematosus. Lupus. 2007;16:593–9.

    Article  CAS  PubMed  Google Scholar 

  101. Silva CA, Hallak J, Pasqualotto FF, Barba MF, Saito MI, Kiss MH. Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus. J Rheumatol. 2002;29:2000–5.

    PubMed  Google Scholar 

  102. Soares PM, Borba EF, Bonfa E, Hallak J, Correa AL, Silva CA. Gonad evaluation in male systemic lupus erythematosus. Arthritis Rheum. 2007;56:2352–61.

    Article  PubMed  Google Scholar 

  103. Moraes AJP, Pereira RMR, Cocuzza M, Casemiro R, Saito O, Silva CAA. Minor sperm abnormalities in young male post-pubertal patients with juvenile dermatomyositis. Braz J Med Biol Res. 2008;41:1142–7.

    Article  CAS  PubMed  Google Scholar 

  104. Prasad AS. Clinical, endocrinologic, and biochemical effects of zinc deficiency. Spec Top Endocrinol Metab. 1985;7:45–76.

    CAS  PubMed  Google Scholar 

  105. Zago MP, Oteiza PI. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med. 2001;31:266–74.

    Article  CAS  PubMed  Google Scholar 

  106. Chimienti F, Aouffen M, Favier A, Seve M. Zinc homeostasis regulating proteins: new drug targets for triggering cell fate. Curr Drug Targets. 2003;4:323–38.

    Article  CAS  PubMed  Google Scholar 

  107. Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update. 2007;13:163–74.

    Article  CAS  PubMed  Google Scholar 

  108. Hunt CD, Johnson PE, Herbel J, Mullen LK. Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Am J Clin Nutr. 1992;56:148–57.

    CAS  PubMed  Google Scholar 

  109. Del Río Prado AF, Reza Albarrán AA, Gómez Pérez FJ. Hombre de 31 años con polineuropatía, postración e hipogonadismo. Gac Med Mex. 2015;151:256–9.

    PubMed  Google Scholar 

  110. Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG. The effects of Hodgkin’s disease and combination chemotherapy on gonadal function in adult male. Cancer. 1982;49:418–22.

    Article  CAS  PubMed  Google Scholar 

  111. Rowley MJ, Leach DR, Warner GA, Heller CG. Effect of graded doses of ionizing radiation on the human testis. Radiat Res. 1974;59:665–78.

    Article  CAS  PubMed  Google Scholar 

  112. Meistrich ML, Beek MEAB. Radiation sensitivity of the human testis. Adv Radiat Biol. 1990;14:227–68.

    Article  Google Scholar 

  113. da Cuhna MF, Meistrich E, Giusti ML, Fuller LM, Cundiff JH, Hagmeister FB, et al. Recovery of spermatogenesis after treatment for Hodgkin’s disaes: limiting dose of MOPP chemotherapy. J Clin Oncol. 1984;2:571–7.

    Google Scholar 

  114. Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G. Gonadal toxicity after combination chemotherapy for Hodgkin’s disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol. 1985;21:601–5.

    Article  CAS  PubMed  Google Scholar 

  115. ISFP Practice Committee, Kim SS, Donnez J, Barri P, Pellicer A, Patrizio P, et al. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet. 2012;29:465–8.

    Article  PubMed Central  Google Scholar 

  116. Handelsman DJ. Testicular dysfunction in systemic diseases. In: Nieschlag E, Behre HM, editors. Andrology. Berlin: Springer-Verlag; 1997. p. 228.

    Google Scholar 

  117. Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Adverse effects of 5α-reductase inhibitors: what do we know, don’t know, and need to know? Rev Endocr Metab Disord. 2015;16:177–98.

    Article  CAS  PubMed  Google Scholar 

  118. Şalvarci A, Istanbulluoğlu O. Secondary infertility due to use of low-dose finasteride. Int Urol Nephrol. 2013;45:83–5.

    Article  PubMed  Google Scholar 

  119. Narasimhalu CRV. Randomized questionnaire based case–control research study on evaluation of sexual function in Indian patients taking oral finasteride for androgenetic alopecia. Dermatol Ther (Heidelb). 2015;5:231–4.

    Article  CAS  Google Scholar 

  120. Qian SZ, Hu YZ, Wang SM, Luo Y, Tang AS, Shu SY, et al. Effects of Tripterygium hypoglaucum (Lévl.) Hutch on male fertility. Adv Contracept. 1988;4:307–10.

    Article  CAS  PubMed  Google Scholar 

  121. Ilani N, Swerdloff RS, Wang C. Male hormonal contraception: potential risks and benefits. Rev Endocr Metab Disord. 2011;12:107–17.

    Article  CAS  PubMed  Google Scholar 

  122. Chao JH, Page ST. The current state of male hormonal contraception. Pharmacol Ther. 2016;163:109–17.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Andrology and STIs, Ain Shams University, 4 Al Rahman Tower, El Sawah Square, Cairo, 11281, Egypt

    M. Badawy Abdel-Naser

  2. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

    M. Badawy Abdel-Naser & Christos C. Zouboulis

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  1. M. Badawy Abdel-Naser
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  2. Christos C. Zouboulis
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Correspondence to M. Badawy Abdel-Naser.

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Abdel-Naser, M.B., Zouboulis, C.C. Male fertility and skin diseases. Rev Endocr Metab Disord 17, 353–365 (2016). https://doi.org/10.1007/s11154-016-9368-x

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