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Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

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Pharmaceutical Chemistry Journal Aims and scope

New α-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et2O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.

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Authors and Affiliations

  1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 26 Prosp. Azatutyan, 0014, Yerevan, Armenia

    G. A. Gevorgyan, N. K. Gasparyan, O. A. Papoyan, D. A. Avakimyan & A. A. Tatevosyan

  2. Molecular Structure Research Center, National Academy of Sciences of Armenia, 26 Prosp. Azatutyan, 0014, Yerevan, Armenia

    H. A. Panosyan

Authors
  1. G. A. Gevorgyan
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  2. N. K. Gasparyan
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  3. O. A. Papoyan
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  4. D. A. Avakimyan
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  5. A. A. Tatevosyan
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  6. H. A. Panosyan
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Corresponding author

Correspondence to G. A. Gevorgyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 2, pp. 19 – 22, February, 2017.

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Gevorgyan, G.A., Gasparyan, N.K., Papoyan, O.A. et al. Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides. Pharm Chem J 51, 107–110 (2017). https://doi.org/10.1007/s11094-017-1565-8

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  • DOI: https://doi.org/10.1007/s11094-017-1565-8

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