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Synthesis and Biological Activity of Mono- and Dibromo Derivatives of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic Acids

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Abstract

The previously unknown mono- and dibromo derivatives of 2-amino-5-(2-aryl-2-oxo-ethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic acids were synthesized. Antinociceptive and antimicrobial activity of the obtained compounds was studied.

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References

  1. Lisovenko, N.U., Dryakhlov, A.V., and Makhmudov, R.R., Pharm. Chem. J., 2014, vol. 48, no. 1, p. 18. doi 10.1007/s11094-014-1036-4

    Article  CAS  Google Scholar 

  2. Kryl’skii, D.V. and Slivkin, A.I., Geterotsiklicheskie lekarstvennye veshchestva (lekarstvennye veshchestva s geterotsiklicheskoi strukturoi) [Heterocyclic Drugs (Drugs with Heterocyclic Structure)], Voronezh: Voronezhskii Gosudarstvennyi Universitet, 2007.

    Google Scholar 

  3. Ivanov, D.V., Igidov, N.M., and Rubtsov, A.E., Russ. J. Org. Chem., 2016, vol. 52, no. 5, p. 676. doi 10.1134/S1070428016050109

    Article  CAS  Google Scholar 

  4. CrysAlisPro. Agilent Technologies. Version 1.171.37.33 (release 27-03-2014 CrysAlis171. NET).

  5. Sheldrick, G.M., Acta Crystallogr. (A), 2008, vol. 64, no. 1, p. 112. doi 10.1107/S0108767307043930.

    Article  CAS  Google Scholar 

  6. Eddy, N.B. and Leimbach, D.J., J. Pharmacol. Exp. Ther., 1953, vol. 107, no. 3, p.385.

    CAS  PubMed  Google Scholar 

  7. Khabriev, R.U., Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv [Guide onEexperimental (Pre-Clinical) Study of New Pharmacological Substances], Moscow: Meditsina, 2005.

    Google Scholar 

  8. Belen’kiy, M.L., Elementy kolichestvennoy otsenki farmakologicheskogo effekta (Elements of Quantitative Evaluation of the Pharmacological Effect), Leningrad: Medgiz, 1963.

    Google Scholar 

  9. Mironov, A.N., Rukovodstvo po provedeniyu doklinicheskikh issledovanii lekarstvennykh veshchestv (Guidelines for Conducting Preclinical Studies of Drugs), Moscow: Grif i K, 2012, Pt1.

    Google Scholar 

  10. Padeiskaya, E.N., Infektsii i antimikrobnaya terapiya, 2001, no. 5, p.150.

    Google Scholar 

  11. Pavlov, P.T., Lesnov, A.E., and Toleneva, A.F., Khim. Zh. Ural’sk. Univ., 2002, no. 3, p. 122.

    Google Scholar 

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Authors and Affiliations

  1. Perm State National Research University, ul. Bukireva 15, Perm, 614990, Russia

    M. V. Dmitriev, D. V. Ivanov & R. R. Makhmudov

  2. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, Perm, Russia

    D. V. Ivanov, N. M. Igidov & V. V. Novikova

  3. Research Institute for Chemistry, Lobachevskii State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    I. N. Chernov

Authors
  1. M. V. Dmitriev
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  2. D. V. Ivanov
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  3. N. M. Igidov
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  4. R. R. Makhmudov
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  5. V. V. Novikova
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  6. I. N. Chernov
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Corresponding author

Correspondence to D. V. Ivanov.

Additional information

Original Russian Text © M.V. Dmitriev, D.V. Ivanov, N.M. Igidov, R.R. Makhmudov, V.V. Novikova, I.N. Chernov, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 7, pp. 1105–1109.

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Dmitriev, M.V., Ivanov, D.V., Igidov, N.M. et al. Synthesis and Biological Activity of Mono- and Dibromo Derivatives of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic Acids. Russ J Gen Chem 88, 1397–1401 (2018). https://doi.org/10.1134/S1070363218070083

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  • DOI: https://doi.org/10.1134/S1070363218070083

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