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Angiotensin AT1 Receptors and Their Ligands (Review)

  • MOLECULAR BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This review addresses on the most intensely studied biological targets in the body – type 1 angiotensin receptors. Particular attention is focused on receptor structure and its interaction with various intracellular signal molecules. Data on long-known and newly created ligands able to influence AT1 receptors are presented. The individual structural fragments of AT1 antagonist molecules with functional significance for this type of activity are described. The review includes a brief analysis of the potentials for the clinical use of AT1 antagonists in a number of pathological states additional to the registered indications, including arterial hypertension, chronic heart failure, and nephropathy in type 2 diabetes mellitus. These results from the discovery of additional aspects of the mechanism of action of antagonists and their ability to produce effects such as neuroprotective and anti-inflammatory actions, as well as various organ-protective properties.

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Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    A. A. Spasov, D. S. Yakovlev & A. A. Brigadirova

  2. Volgograd Medical Scientific Center, Volgograd, Russia

    A. A. Spasov, D. S. Yakovlev & A. A. Brigadirova

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  1. A. A. Spasov
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  2. D. S. Yakovlev
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  3. A. A. Brigadirova
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Correspondence to D. S. Yakovlev.

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Spasov, A.A., Yakovlev, D.S. & Brigadirova, A.A. Angiotensin AT1 Receptors and Their Ligands (Review). Pharm Chem J 51, 1–8 (2017). https://doi.org/10.1007/s11094-017-1546-y

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