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Prospects for Using Gold, Silver, and Iron Oxide Nanoparticles for Increasing the Efficacy of Chemotherapy

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Pharmaceutical Chemistry Journal Aims and scope

Modern concepts about nanosized conjugates of gold, silver, and iron oxide nanoparticles with antitumor drugs that are intended for chemotherapy of oncological diseases are reviewed. The main possibilities for increasing the safety and efficacy of chemotherapy with the aid of such metal-nanoparticle—antitumor-drug conjugates are shown. Among these possibilities, the most important in practice are targeted drug delivery, controlled drug release, and suppression of multiple drug resistance of tumor cells. An analysis of the advantages and drawbacks of biomedical applications of various metal nanoparticles for antitumor therapy shows good prospects for using conjugates of iron oxide nanoparticles with antitumor drugs, in particular, with doxorubicin. The expediency of creating these nanocomplexes is justified by the possibility of their magnetic-driven delivery, controlled biodistribution, selective toxicity, and relatively simple synthesis.

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, Moscow, 117997, Russia

    T. A. Fedotcheva, K. M. Starostin & N. L. Shimanovskii

  2. Moscow State University, Moscow, 119991, Russia

    A. Yu. Olenin & G. V. Lisichkin

  3. Scientific Center for Biomedical Technologies, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia

    T. A. Fedotcheva & V. V. Banin

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  1. T. A. Fedotcheva
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 4, pp. 11 – 22, April, 2015.

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Fedotcheva, T.A., Olenin, A.Y., Starostin, K.M. et al. Prospects for Using Gold, Silver, and Iron Oxide Nanoparticles for Increasing the Efficacy of Chemotherapy. Pharm Chem J 49, 220–230 (2015). https://doi.org/10.1007/s11094-015-1260-6

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