Complex formation of 1-(3-n-butoxypropyl)-4-vinylacetylene-4-benzoyloxypiperidine with β-cyclodextrin was studied by NMR spectroscopy. The structural characteristics and composition (1:2) of the resulting inclusion complex of 1-(3-n-butoxypropyl)-4-vinylacetylene-4-benzoyloxypiperidine with β-cyclodextrin in aqueous solution were identified. The local anesthetic activity of the resulting preparation was assessed; the complex was found to have greater anesthetic activity greater than reference agents.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 3, pp. 41 – 45, March, 2014.
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Kaldybekova, G.M., Kemel’bekov, U.S., Abdildanova, A.A. et al. Preparation of an Inclusion Complex of 1-(3-n-butoxypropyl)-4-vinylacetylen-4-benzoyloxypiperidine with B-cyclodextrin and its Local Anesthetic Activity. Pharm Chem J 48, 196–200 (2014). https://doi.org/10.1007/s11094-014-1076-9
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DOI: https://doi.org/10.1007/s11094-014-1076-9