3,5-Diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones were prepared by the reaction of methyl-1-bromocycloheptane carboxylates with zinc and 1,3-diarylprop-2-en-1-ones. The synthesized compounds possessed analgesic activity and exhibited low toxicity.
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The work was supported financially by the Ministry of the RF for Education and Science (Project 1.12.11).
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Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 47, No. 1, pp. 41-42, January, 2013.
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Kirillov, N.F., Makhmudov, R.R., Gavrilov, A.G. et al. Synthesis and analgesic activity of 3,5-diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones. Pharm Chem J 47, 40–41 (2013). https://doi.org/10.1007/s11094-013-0892-7
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DOI: https://doi.org/10.1007/s11094-013-0892-7