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Synthesis and Analgesic Activity of 9-Aryl-12-Imino-10,11-Dioxatricyclo[5.3.2.01,6]Dodecane-7,8,8-Tricarbonitriles and 3-Aryl-1,1,2,2-Tetracyanocyclopropanes

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9-Aryl-12-imino-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitriles were synthesized via the reaction of 1-(2-oxocyclohexyl)ethane-1,1,2,2-tetracarbonitrile with aromatic aldehydes. The corresponding 3-aryl-1,1,2,2-tetracyanocyclopropanes were prepared from bromomalononitrile and aromatic aldehydes. The structures of the synthesized compounds were elucidated using IR, PMR, 13C NMR, and mass spectra. The analgesic activity of the synthesized compounds was investigated.

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Acknowledgments

The work was sponsored by RSF Grant No. 15-13-10029.

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Authors and Affiliations

  1. I. N. Ul’yanov Chuvash State University, Cheboksary, Chuvash Republic, 428010, Russia

    M. A. Mar’yasov, V. P. Sheverdov & O. E. Nasakin

  2. Perm State University, Perm, 614990, Russia

    R. R. Makhmudov

Authors
  1. M. A. Mar’yasov
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  2. V. P. Sheverdov
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  3. O. E. Nasakin
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  4. R. R. Makhmudov
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Correspondence to M. A. Mar’yasov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 9, pp. 10 – 12, September, 2016.

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Mar’yasov, M.A., Sheverdov, V.P., Nasakin, O.E. et al. Synthesis and Analgesic Activity of 9-Aryl-12-Imino-10,11-Dioxatricyclo[5.3.2.01,6]Dodecane-7,8,8-Tricarbonitriles and 3-Aryl-1,1,2,2-Tetracyanocyclopropanes. Pharm Chem J 50, 580–582 (2016). https://doi.org/10.1007/s11094-016-1494-y

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  • DOI: https://doi.org/10.1007/s11094-016-1494-y

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