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Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain

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Abstract

Many studies note that changes in oxidative balance are involved in the pathogenesis of major depressive disorder (MDD) and in the success of some antidepressants. Quetiapine exerts a therapeutic response and induces changes in physiological mechanisms that appear to underlie MDD. The objective of this study was to evaluate the antidepressant and antioxidant effects of quetiapine (20 mg /kg) in adult animals. Sixty minutes after an acute treatment or the last administration of chronic treatment (14 days) with quetiapine, animals were subjected to the forced swimming test (FST) to evaluate mobility parameters. Then, the hippocampus, prefrontal cortex (CPF), amygdala and nucleus accumbens (NAc) were removed for the assessment of oxidative stress parameters. Both acute and chronic treatments exerted antidepressant-like effects. Myeloperoxidase (MPO) activity was reduced in the amygdala after acute treatment and in the hippocampus, PFC and amygdala after chronic treatment. In addition, after chronic treatment, the levels of thiobarbituric reactive species (TBARS) were reduced in the amygdala and NAc, and the protein carbonyl content was reduced in the CPF. Superoxide dismutase (SOD) activity increased in the NAc after acute and chronic treatments. Catalase (CAT) activity increased in the PFC after acute treatment and in the NAc after acute and chronic treatments. The concentration of nitrite/nitrate was lower in the CPF after chronic treatment. These results corroborate the antidepressant effect of quetiapine and indicate that quetiapine exhibits an antioxidant profile, a physiological mechanism that appears be involved in the therapeutic function of quetiapine in individuals resistant to classical antidepressant treatments.

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Acknowledgements

The Translational Psychiatry Program (USA) is funded by the Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth). Laboratory of Neurosciences (Brazil) is one of the centers of the National Institute for Molecular Medicine (INCT-MM) and one of the members of the Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC). Its research is supported by grants from CNPq (JQ) FAPESC (JQ); Instituto Cérebro e Mente (JQ) and UNESC (JQ and GZR). JQ is 1A CNPq Research Fellow.

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Authors and Affiliations

  1. Laboratório de Neurociências, Unidade Acadêmica em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    Zuleide M. Ignácio, Gislaine Z. Réus, Helena M. Abelaira, Airam B. de Moura, Thays G. de Souza, Danyela Matos & João Quevedo

  2. Laboratório de Fisiologia, Farmacologia e Psicopatologia, Campus Chapecó, Universidade Federal da Fronteira Sul, Chapecó, Santa Catarina, Brazil

    Zuleide M. Ignácio

  3. Laboratório de Patofisiologia Clínica e Experimental, Universidade do Sul de Santa Catarina, Tubarão, SC, Brazil

    Mariana P. Goldim, Khiany Mathias, Leandro Garbossa & Fabricia Petronilho

  4. Center for Translational Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

    João Quevedo

  5. Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

    João Quevedo

  6. Neuroscience Graduate Program, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA

    João Quevedo

Authors
  1. Zuleide M. Ignácio
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  2. Gislaine Z. Réus
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  3. Helena M. Abelaira
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  4. Airam B. de Moura
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  5. Thays G. de Souza
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  6. Danyela Matos
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  7. Mariana P. Goldim
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  8. Khiany Mathias
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  9. Leandro Garbossa
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  10. Fabricia Petronilho
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  11. João Quevedo
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Corresponding author

Correspondence to Gislaine Z. Réus.

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Ignácio, Z.M., Réus, G.Z., Abelaira, H.M. et al. Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain. Metab Brain Dis 32, 1195–1208 (2017). https://doi.org/10.1007/s11011-017-0028-y

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  • DOI: https://doi.org/10.1007/s11011-017-0028-y

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