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Inhibition of AGEs formation, antioxidative, and cytoprotective activity of Sumac (Rhus typhina L.) tannin under hyperglycemia: molecular and cellular study

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Abstract

It is well known that accumulation of advanced glycation ends products (AGEs) lead to various diseases such as diabetes and diabetic complications. In this study we showed that hydrolysable tannin from Sumac (Rhus typhina L.)—3,6-bis-O-di-O-galloyl-1,2,4-tri-O-galloyl-β-d-glucose (C55H40O34) inhibited generation of glycation markers in bovine serum albumin such as AGEs, dityrosine, N′-formylkynurenine and kynurenine under high glucose treatment. This effect was accompanied by stabilization of the protein structure, as was shown using ATR-FT-IR spectroscopy and fluorescence methods. C55H40O34 exhibited also a neuroprotective effect in high glucose-exposed Neuro2A cells suppressing ROS formation and expression of phospho NF-κβ and iNOS. At the same time C55H40O34 increased expression of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase and mitochondrial complex I and V activities. Results from this study demonstrates a potent antiglycation activity of C55H40O34 in vitro and indicates its possible therapeutic application in glycation related diseases.

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Data availability

All the data generated or analyzed during this study are included in this published article.

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Abbreviations

AGEs:

Advanced glycation end products

ATR-FT-IR:

Attenuated total reflection Fourier-transform infra-red spectroscopy

BSA:

Bovine serum albumin

DCF:

2′,7′-Dichlorofluorescein

d-Tyr:

Dityrosine

FBS:

Fetal bovine serum

H2DCF-DA:

2′,7′-Dichlorodihydrofluorescein diacetate

HO-1:

Heme oxygenase-1

HSA:

Human serum albumin

iNOS:

Nitric oxide synthase

K b :

Binding constant

KN:

Kynurenine

MEM:

Minimum essential medium

N-FKN:

N′-Formylkynurenine

NF-κB:

Nuclear factor kappa B

NQO1:

NAD(P)H:quinone oxidoreductase

PBS:

Phosphate buffer saline

PGG:

1,2,3,4,6-Penta-O-galloyl-β-d-glucose

RCS:

Reactive carbonyl species

RIPA buffer:

Radioimmunoprecipitation assay buffer

ROS:

Reactive oxygen species

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Acknowledgements

This work was supported by Department of Science and Technology (DST), Government of India and Ministry of Science and Higher Education of Poland in the frame of Indo-Poland bilateral Cooperation scheme. The Authors like to thanks M.Sc. Anna Roszkowska from the Laboratory of Molecular Biophysics (University of Bialystok, Poland) for technical assistance.

Funding

This work was supported by Department of Science and Technology (DST), Government of India and Ministry of Science and Higher Education of Poland in the frame of Indo-Poland bilateral Cooperation scheme.

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Authors and Affiliations

  1. Department of Microbiology and Biotechnology, Laboratory of Molecular Biophysics, Faculty of Biology, University of Bialystok, Ciołkowskiego 1J, 15-245, Białystok, Poland

    Szymon Sekowski, Ewa Olchowik-Grabarek, Paula Markiewicz & Maria Zamaraeva

  2. Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, Ciołkowskiego 1K, 15-245, Białystok, Poland

    Alina T. Dubis

  3. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, West Bengal, India

    Lokesh Sharan & Ashutosh Kumar

  4. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Balanagar, India

    Ashutosh Kumar

  5. Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Abdullaev Street 83, Tashkent, Uzbekistan, 100143

    Nodira Abdulladjanova

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  1. Szymon Sekowski
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  2. Ewa Olchowik-Grabarek
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  7. Paula Markiewicz
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Contributions

SS: conceptualization, methodology, software, investigation, formal analysis, writing original draft preparation, EO-G: methodology, investigation, writing—review& editing, ATD: investigation, writing—review & editing, LS: investigation, AK: investigation, methodology, writing—review & editing, NA: Investigation, PM: investigation, MZ: writing—review & editing.

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Correspondence to Szymon Sekowski.

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Sekowski, S., Olchowik-Grabarek, E., Dubis, A.T. et al. Inhibition of AGEs formation, antioxidative, and cytoprotective activity of Sumac (Rhus typhina L.) tannin under hyperglycemia: molecular and cellular study. Mol Cell Biochem 478, 443–457 (2023). https://doi.org/10.1007/s11010-022-04522-0

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