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miR-526a regulates apoptotic cell growth in human carcinoma cells

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Abstract

MicroRNAs (miRNAs) play vital roles in the regulation of cell cycle, cell growth, apoptosis, and tumorigenesis. Our previous studies showed that miR-526a positively regulated innate immune response by suppressing CYLD expression, however, the functional relevance of miR-526a expression and cell growth remains to be evaluated. In this study, miR-526a overexpression was found to promote cancer cell proliferation, migration, and anchor-independent colony formation. The molecular mechanism(s) of miR-526a-mediated growth stimulation is associated with rapid cell cycle progression and inhibition of cell apoptosis by targeting CYLD. Taken together, these results provide evidence to show the stimulatory role of miR-526a in tumor migration and invasion through modulation of the canonical NF-κB signaling pathway.

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Acknowledgments

This work was supported by Grants from the Beijing Municipal Science & Technology Commission (Z121107005112012) and General Hospital of Chinese People’s Armed Police Forces (WZ 2011021 and WZ 2010016).

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    Authors and Affiliations

    1. Beijing Institute of Biotechnology, Beijing, 100850, China

      Xiaoli Yang, Changzhi Xu, Congwen Wei, Kai Guan, Shengli Ma, Ye Cao, Xiang He, Qingjun Ma & Zirui Zheng

    2. The General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, China

      Xiaoli Yang, Cui Wang, Liping Liu & Deyong Zou

    3. Gynecology and Obstetrics Department of Chinese PLA General Hospital, Beijing, 100853, China

      Zhifeng Yan

    4. College of Clinical Medicine, General Hospital of Armed Police Forces, Anhui Medical University, Hefei, 230032, China

      Cui Wang

    5. Institute of Health Science, School of Life Sciences, Anhui University, Hefei, 230601, Anhui, China

      Buchang Zhang & Zirui Zheng

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    1. Xiaoli Yang
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    Correspondence to Buchang Zhang, Qingjun Ma or Zirui Zheng.

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    Xiaoli Yang, Cui Wang, Changzhi Xu and Zhifeng Yan have contributed equally to this work.

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    Yang, X., Wang, C., Xu, C. et al. miR-526a regulates apoptotic cell growth in human carcinoma cells. Mol Cell Biochem 407, 69–76 (2015). https://doi.org/10.1007/s11010-015-2455-6

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    • DOI: https://doi.org/10.1007/s11010-015-2455-6

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