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Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats

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Abstract

Diabetic nephropathy (DN) is one of the foremost causes of renal failure and a primary cause of diabetes mellitus related death. Previously, we have reported that aqueous extract of Enicostemma littorale has potential antidiabetic activity. In the present study, we have investigated the effect of aqueous extract of E. littorale 1 g/kg, p.o. and swertiamarin 50 mg/kg, p.o. daily for 3 weeks in type 1 DN complications in SD rats. DN was assessed by serum urea, creatinine, lipid profile and water intake levels. Treatment with aqueous extract of E. littorale and swertiamarin significantly decreased serum urea and creatinine and other parameters associated with the development of DN in type 1 diabetic rats. We have also found considerable improvement in histology of glomerular function of aqueous extract of E. littorale and swertiamarin-treated animals.

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Acknowledgements

Authors acknowledge the financial grant provided by Department of Science and Technology, New Delhi.

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  1. Ramesh K. Goyal

    Present address: Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kala Bhavan, Vadodara, 390 001, India

Authors and Affiliations

  1. Department of Pharmacology, L.M. College of Pharmacy, P.O. Box 4011, Navrangpura, Ahmedabad, 380 009, India

    Rakesh D. Sonawane, Santosh L. Vishwakarma & Ramesh K. Goyal

  2. B.V. Patel Pharmaceutical Education and Research Development Center, Thaltej, Ahmedabad, 380 054, India

    S. Lakshmi, Mandapati Rajani & Harish Padh

  3. Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kala Bhavan, Vadodara, 390 001, India

    Rakesh D. Sonawane

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  1. Rakesh D. Sonawane
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  2. Santosh L. Vishwakarma
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Correspondence to Ramesh K. Goyal.

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Sonawane, R.D., Vishwakarma, S.L., Lakshmi, S. et al. Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol Cell Biochem 340, 1–6 (2010). https://doi.org/10.1007/s11010-010-0393-x

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