Abstract
The Ca, Cl, Mg, Na, and P content and Ca/P, Ca/Mg, Ca/Na, Cl/Ca, and Cl/Na ratios in tissue of intact bone, chondroma and chondrosarcoma were investigated by neutron activation analysis. It was shown that higher mass fraction of Cl and Na and also Cl/Na mass fraction ratio as well as lower Ca/Cl and Ca/Na mass fraction ratios are typical of the chondrosarcoma tissue compared to chondroma. Finally, it was proposed to use the estimation of such parameters as the Cl mass fraction and the Ca/Cl and Ca/Na mass fraction ratios as an additional test for differential diagnosis between chondroma and chondrosarcoma.
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Acknowledgments
We are grateful to the late Prof. V. A. Bizer, Medical Radiological Research Center, Obninsk, for supplying chondroma and chondrosarcoma samples.
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Zaichick, V., Zaichick, S. The distinction between chondroma and chondrosarcoma using chemical element mass fractions in tumors determined by neutron activation analysis as diagnostic markers. J Radioanal Nucl Chem 309, 285–293 (2016). https://doi.org/10.1007/s10967-016-4810-9
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DOI: https://doi.org/10.1007/s10967-016-4810-9