Skip to main content
Log in

The Impact of Race on Metabolic Disease Risk Factors in Women With and Without Posttraumatic Stress Disorder

  • Published:
Journal of Clinical Psychology in Medical Settings Aims and scope Submit manuscript

Abstract

The literature on PTSD and metabolic disease risk factors has been limited by lacking investigation of the potential influence of commonly comorbid disorders and the role of race. In this study data were provided by a sample of 134 women (63 PTSD and 71 without PTSD). Separate sets of models examining associations of psychiatric disorder classifications with metabolic disease risk factors were used. Each model included race (African American or Caucasian), psychiatric disorder, and their interaction. There was an interaction of race and PTSD on body mass index, abdominal obesity, and triglycerides. While PTSD was not generally associated with deleterious health effects in African American participants, PTSD was related to worse metabolic disease risk factors in Caucasians. MDD was associated with metabolic disease risk factors, but there were no interactions with race. Results support the importance of race in the relationship between PTSD and metabolic disease risk factors. Future research would benefit from analysis of cultural factors to explain how race might influence metabolic disease risk factors in PTSD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Babic, D., Jakovljevic, M., Martinac, M., Saric, M., Topic, R., & Maslov, B. (2007). Metabolic syndrome and combat post-traumatic stress disorder intensity: Preliminary findings. Psychiatria Danubina, 19, 68–75.

    PubMed  Google Scholar 

  • Beckham, J. C., Flood, A. M., Dennis, M. F., & Calhoun, P. S. (2009). Ambulatory cardiovascular activity and hostility ratings in women with chronic posttraumatic stress disorder. Biological Psychiatry, 65, 268–272.

    Article  PubMed  Google Scholar 

  • Beckham, J. C., Moore, S. D., Feldman, M. E., Hertzberg, M. A., Kirby, A. C., & Fairbank, J. A. (1998). Health status, somatization, and severity of posttraumatic stress disorder in Vietnam combat veterans with posttraumatic stress disorder. American Journal of Psychiatry, 155, 1565–1569.

    PubMed  CAS  Google Scholar 

  • Betancourt, H., & Lopez, S. R. (1993). The study of culture, ethnicity, and race in American psychology. American Psychologist, 48, 629–637.

    Article  Google Scholar 

  • Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., et al. (1995). The development of a clinician-administered posttraumatic stress disorder scale. Journal of Traumatic Stress, 8, 75–80.

    Article  PubMed  CAS  Google Scholar 

  • Boscarino, J. A. (1997). Diseases among men 20 years after exposure to severe stress: Implications for clinical research and medical care. Psychosomatic Medicine, 59, 605–614.

    PubMed  CAS  Google Scholar 

  • Breslau, N. (2001). The epidemiology of posttraumatic stress disorder: What is the extent of the problem? Journal of Clinical Psychiatry, 62, 16–22.

    PubMed  Google Scholar 

  • Calhoun, P. S., Wiley, M., Dennis, M. F., & Beckham, J. C. (2009). Self-reported health and physician diagnosed illnesses in women with posttraumatic stress disorder and major depressive disorder. Journal of Traumatic Stress, 22, 122–130.

    Article  PubMed  Google Scholar 

  • Campbell, D. G., Felker, B. L., Liu, C. F., Yano, E. M., Kirchner, J. E., Chan, D., et al. (2007). Prevalence of depression-PTSD comorbidity: Implications for clinical practice guidelines and primary care-based interventions. Journal of General Internal Medicine, 22, 711–718.

    Article  PubMed  Google Scholar 

  • Carson, M. A., Metzger, L. J., Lasko, N. B., Paulus, L. A., Morse, A. E., Pitman, R. K., et al. (2007). Physiologic reactivity to startling tones in female Vietnam nurse veterans with PTSD. Journal of Traumatic Stress, 20, 657–666.

    Article  PubMed  Google Scholar 

  • David, D., Woodward, C., Esquenazi, J., & Mellman, T. A. (2004). Comparison of comorbid physical illnesses among veterans with PTSD and veterans with alcohol dependence. Psychiatric Services, 55, 82–85.

    Article  PubMed  Google Scholar 

  • Davidson, K., Jonas, B. S., Dixon, K. E., & Markovitz, J. H. (2000). Do depression symptoms predict early hypertension incidence in young adults in the CARDIA study? Coronary artery risk development in young adults. Archives of Internal Medicine, 160, 1495–1500.

    Article  PubMed  CAS  Google Scholar 

  • Dedert, E. A., Becker, M. E., Fuemmeler, B. F., Braxton, L. E., Calhoun, P. S., & Beckham, J. C. (2010a). Childhood traumatic stress and obesity in women: The intervening effects of PTSD and MDD. Journal of Traumatic Stress, 23, 763–785.

    Article  Google Scholar 

  • Dedert, E. A., Calhoun, P. S., Watkins, L. L., Sherwood, A., & Beckham, J. C. (2010b). Posttraumatic stress disorder, cardiovascular and metabolic disease: A review of the evidence. Annals of Behavioral Medicine, 39, 61–78.

    Article  PubMed  Google Scholar 

  • Dennis, M. F., Flood, A. M., Reynolds, V., Araujo, G., Clancy, C. P., Barefoot, J. C., et al. (2009). Evaluation of lifetime trauma exposure and physical health in women with posttraumatic stress disorder or major depressive disorder. Violence Against Women, 15, 618–627.

    Article  PubMed  Google Scholar 

  • Dobie, D. J., Kivlahan, D. R., Maynard, C., Bush, K. R., Davis, T. M., & Bradley, K. A. (2004). Posttraumatic stress disorder in female veterans: Association with self-reported health problems and functional impairment. Archives of Internal Medicine, 164, 394–400.

    Article  PubMed  Google Scholar 

  • Eaton, C. A. (1996). Depression and risk for onset of type II diabetes. A prospective population-based study. Diabetes Care, 19, 1097–1102.

    Article  PubMed  CAS  Google Scholar 

  • Ervin, R. B. (2009). Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 20032006.

  • First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997). Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, D.C.: American Psychiatric Press, Inc.

    Google Scholar 

  • Flegal, K. M., Carroll, M. D., Ogden, C. L., & Curtin, L. R. (2010). Prevalence and trends in obesity among US adults. JAMA, 303, 235–241.

    Article  PubMed  CAS  Google Scholar 

  • Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499–502.

    PubMed  CAS  Google Scholar 

  • Gaillard, T., Schuster, D., & Osei, K. (2009). Metabolic syndrome in Black people of the African Diaspora: The paradox of current classification. definition and criteria. Ethnicity and Disease, 19, S1–S7.

    Google Scholar 

  • Glasgow, A. M., Tynan, D., Schwartz, R., Hicks, J. M., Turek, J., Driscol, C., et al. (1991). Alcohol and drug use in teenagers with diabetes mellitus. Journal of Adolescent Health, 12, 11–14.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, R. D., & Davidson, J. R. (2005). Self-reported diabetes and posttraurnatic stress disorder among adults in the community. Preventive Medicine, 40, 570–574.

    Article  PubMed  Google Scholar 

  • Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004). Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation, 109, 433–438.

    Article  PubMed  Google Scholar 

  • Hollingshead, A. B., & Redlich, R. L. (1958). Social class and mental illness. New York: John Wiley.

    Book  Google Scholar 

  • Jakovljevic, M., Crncevic, Z., Ljubicic, D., Babic, D., Topic, R., & Saric, M. (2007). Mental disorders and metabolic syndrome: A fatamorgana or warning reality? Psychiatria Danubina, 19, 76–86.

    PubMed  CAS  Google Scholar 

  • Jakovljevic, M., Saric, M., Nad, S., Topic, R., & Vuksan-Cusa, B. (2006). Metabolic syndrome, somatic and psychiatric comorbidity in war veterans with post-traumatic stress disorder: Preliminary findings. Psychiatria Danubina, 18, 169–176.

    PubMed  Google Scholar 

  • Jin, H., Meyer, J. M., & Jeste, D. V. (2004). Atypical antipsychotics and glucose dysregulation: A systematic review. Schizophrenia Research, 71, 195–212.

    Article  PubMed  Google Scholar 

  • Katon, W., & Ciechanowski, P. (2002). Impact of major depression on chronic medical illness. Journal of Psychosomatic Research, 53, 859–863.

    Article  PubMed  Google Scholar 

  • Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593–602.

    Article  PubMed  Google Scholar 

  • Kessler, R. C., Sonnega, A., Bromet, E., Hughes, M., & Nelson, C. B. (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry, 52, 1048–1060.

    Article  PubMed  CAS  Google Scholar 

  • Kinder, L. S., Carnethon, M. R., Palaniappan, L. P., King, A. C., & Fortmann, S. P. (2004). Depression and the metabolic syndrome in young adults: Findings from the Third National Health and Nutrition Examination Survey. Psychosomatic Medicine, 66, 316–322.

    Article  PubMed  Google Scholar 

  • Kurella, M., Lo, J. C., & Chertow, G. M. (2005). Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. Journal of the American Society of Nephrology, 16, 2134–2140.

    Article  PubMed  Google Scholar 

  • Miller, G. A., & Chapman, J. P. (2001). Misunderstanding analysis of covariance. Journal of Abnormal Psychology, 110, 40–48.

    Article  PubMed  CAS  Google Scholar 

  • Ng, R. S., Darko, D. A., & Hillson, R. M. (2004). Street drug use among young patients with type 1 diabetes in the UK. Diabetes Medicine, 21, 295–296.

    Article  CAS  Google Scholar 

  • Osei, K. (2010). Metabolic syndrome in blacks: Are the criteria right? Current Diabetes Reports, 10, 199–208.

    Article  PubMed  Google Scholar 

  • Perilla, J. L., Norris, F. H., & Lavizzo, E. A. (2002). Ethnicity, culture, and disaster response: Identifying and explaining ethnic differences in PTSD six months after Hurricane Andrew. Journal of Social and Clinical Psychology, 21, 20–45.

    Article  Google Scholar 

  • Perkonigg, A., Owashi, T., Stein, M. B., Kirschbaum, C., & Wittchen, H. U. (2009). Posttraumatic stress disorder and obesity: Evidence for a risk association. American Journal of Preventive Medicine, 36, 1–8.

    Article  PubMed  Google Scholar 

  • Raikkonen, K., Matthews, K. A., & Kuller, L. H. (2001). Trajectory of psychological risk and incident hypertension in middle-aged women. Hypertension, 38, 798–802.

    PubMed  CAS  Google Scholar 

  • Raikkonen, K., Matthews, K. A., & Kuller, L. H. (2002). The relationship between psychological risk attributes and the metabolic syndrome in healthy women: Antecedent or consequence? Metabolism, 51, 1573–1577.

    Article  PubMed  CAS  Google Scholar 

  • Raikkonen, K., Matthews, K. A., Kuller, L. H., Reiber, C., & Bunker, C. H. (1999). Anger, hostility, and visceral adipose tissue in healthy postmenopausal women. Metabolism, 48, 1146–1151.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, A. L., Gilman, S. E., Breslau, J., Breslau, N., & Koenen, K. C. (2011). Race/ethnic differences in exposure to traumatic events, development of posttraumatic stress disorder, and the treatment-seeking for posttraumatic stress disorder in the Unites States. Psychological Medicine, 41, 71–83.

    Article  PubMed  CAS  Google Scholar 

  • Schnurr, P. P., & Green, B. L. (Eds.). (2004). Understanding relationships among trauma, posttraumatic stress disorder, and health outcomes. Washington: American Psychological Association.

    Google Scholar 

  • Sumner, A. E. (2009). Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults. Journal of Pediatrics, 155, S7 e7–S7 e11.

    Google Scholar 

  • Trief, P. M., Ouimette, P., Wade, M., Shanahan, P., & Weinstock, R. S. (2006). Post-traumatic stress disorder and diabetes: Co-morbidity and outcomes in a male veterans sample. Journal of Behavioral Medicine, 29, 411–418.

    Article  PubMed  Google Scholar 

  • Vieweg, W. V., Julius, D. A., Bates, J., Quinn, J. F., 3rd, Fernandez, A., Hasnain, M., et al. (2007). Posttraumatic stress disorder as a risk factor for obesity among male military veterans. Acta Psychiatrica Scandinavica, 116, 483–487.

    Article  PubMed  CAS  Google Scholar 

  • Violanti, J. M., Fekedulegn, D., Hartley, T. A., Andrew, M. E., Charles, L. E., Mnatsakanova, A., et al. (2006). Police trauma and cardiovascular disease: Association between PTSD symptoms and metabolic syndrome. International Journal of Emergency Mental Health, 8, 227–237.

    PubMed  Google Scholar 

  • Virmani, A., Binienda, Z., Ali, S., & Gaetani, F. (2006). Links between nutrition, drug abuse, and the metabolic syndrome. Annals of the New York Academy of Science, 1074, 303–314.

    Article  CAS  Google Scholar 

  • Vrana, S. R., Hughes, J. W., Dennis, M. F., Calhoun, P. S., & Beckham, J. C. (2009). Effects of posttraumatic stress disorder status and covert hostility on cardiovascular responses to relived anger in women with and without PTSD. Biological Psychology, 82, 274–280.

    Article  PubMed  Google Scholar 

  • Warnick, G. R., Benderson, J., & Albers, J. J. (1983). Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density lipoprotein cholesterol. In G. R. Cooper (Ed.), Selected methods of clinical chemistry (Vol. 10, pp. 91–99). Washington, DC.

  • Wassertheil-Smoller, S., Shumaker, S., Ockene, J., Talavera, G. A., Greenland, P., Cochrane, B., et al. (2004). Depression and cardiovascular sequelae in postmenopausal women. The Women’s Health Initiative (WHI). Archives of Internal Medicine, 164, 289–298.

    Article  PubMed  Google Scholar 

  • Weathers, F. W., Keane, T. M., & Davidson, J. R. (2001). Clinician-Administered PTSD Scale: A review of the first ten years of research. Depression & Anxiety, 13, 132–156.

    Article  CAS  Google Scholar 

  • Weathers, F. W., Ruscio, A. M., & Keane, T. M. (1999). Psychometric properties of nine scoring rules for the Clinician-Administered Posttraumatic Stress Disorder Scale. Psychological Assessment, 11, 124–133.

    Article  Google Scholar 

  • Weisberg, R. B., Bruce, S. E., Machan, J. T., Kessler, R. C., Culpepper, L., & Keller, M. B. (2002). Nonpsychiatric illness among primary care patients with trauma histories and posttraumatic stress disorder. Psychiatric Services, 53, 848–854.

    Article  PubMed  Google Scholar 

  • Wirshing, D. A., Boyd, J. A., Meng, L. R., Ballon, J. S., Marder, S. R., & Wirshing, W. C. (2002). The effects of novel antipsychotics on glucose and lipid levels. Journal of Clinical Psychiatry, 63, 856–865.

    Article  PubMed  CAS  Google Scholar 

  • Zanarini, M. C., Skodol, A. E., Bender, D., Dolan, R., Sanislow, C., Schaefer, E., et al. (2000). The collaborative longitudinal personality disorders study: Reliability of axis I and II diagnoses. Journal of Personality Disorders, 14, 291–299.

    Article  PubMed  CAS  Google Scholar 

  • Zeno, S. A., Dueuster, P. A., Davis, J. L., Kim-Dorner, S., Remaley, A. T., & Poth, M. (2010). Diagnostic criteria for metabolic syndrome: Caucasians versus African Americans. Metabolic Syndrome and Related Disorders, 8, 149–156.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank the participants who volunteered for this study. This work was supported in part by the National Institutes of Health Grants R01MH062482, 2K24DA016388, 1R21CA128965, and the Department of Veterans Affairs Office of Research and Development, Clinical Science, Health Services Research and Development Grant # IIR 08-032, and the Mid-Atlantic Mental Illness Research Education and Clinical Center. The authors have no competing interests to report. The views expressed in this presentation are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric A. Dedert.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dedert, E.A., Harper, L.A., Calhoun, P.S. et al. The Impact of Race on Metabolic Disease Risk Factors in Women With and Without Posttraumatic Stress Disorder. J Clin Psychol Med Settings 20, 46–55 (2013). https://doi.org/10.1007/s10880-012-9305-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10880-012-9305-4

Keywords

Navigation