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Diagnosis of Interstitial Lung Disease Caused by Possible Hypersensitivity Pneumonitis in a Child: Think CGD

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Abstract

Interstitial lung disease (ILD) is a rare and heterogeneous group of disorder affecting the lung parenchyma and has a detrimental effect on gas exchange. Chronic granulomatous disease (CGD), when it affects primarily lungs, may cause ILD. We report a 16-year-old patient with CGD caused by homozygous deletion of NCF1 who atypically presented with ILD. The patient had many pigeons and was a pigeon breeder. Exacerbated clinical symptoms were linked to hypersensitivity pneumonitis (HP), and the patient was suggested to keep away from pigeons. In addition to allergen avoidance and prophylactic antibacterial therapy, treatment with corticosteroids and hydroxychloroquine was started for mainly obstructive and persistant symptoms of ILD. CGD is known to cause a hyperinflammatory state and the patients present with excessive granuloma formation and HP. Control of inflammation either by avoidance of allergen exposure and by anti-inflammatory drugs is necessary for the relief of symptoms.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Immunology, Hacettepe University Faculty of Medicine, Sıhhiye, 06100, Ankara, Turkey

    Saliha Esenboga, Deniz Cagdas, Baran Erman & İlhan Tezcan

  2. Department of Pediatrics, Division of Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Nagehan Emiralioglu & Nural Kiper

  3. Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Martin De Boer

  4. Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Berna Oguz

Authors
  1. Saliha Esenboga
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  2. Nagehan Emiralioglu
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  3. Deniz Cagdas
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  4. Baran Erman
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  5. Martin De Boer
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  6. Berna Oguz
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  7. Nural Kiper
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  8. İlhan Tezcan
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Corresponding author

Correspondence to Saliha Esenboga.

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The study received no funding.

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The authors declare that they have no conflict of interest.

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Esenboga, S., Emiralioglu, N., Cagdas, D. et al. Diagnosis of Interstitial Lung Disease Caused by Possible Hypersensitivity Pneumonitis in a Child: Think CGD. J Clin Immunol 37, 269–272 (2017). https://doi.org/10.1007/s10875-017-0376-8

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  • DOI: https://doi.org/10.1007/s10875-017-0376-8

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