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Naphthyridine-based receptors for flurometric detection of urea and biotin

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Abstract

Naphthyridine-based receptors 1–4 have been designed and synthesized for the recognition of urea in CHCl3 containing 1% CH3CN. Receptor 1 also binds biotin and its methyl ester with moderate binding constant values. In comparison, receptor 2 is less efficient in recognising biotin and its methyl ester analogue. Receptor 1 binds urea and biotin with binding constant values of 1.02 × 104 and 1.08 × 104 M−1, respectively, in CHCl3 containing 1% CH3CN and shows significant change in emission of naphthyridine upon complexation. Characterization and sensing properties of the receptors were evaluated by 1H NMR, UV–vis and fluorescence spectroscopic methods.

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Notes

  1. Energy minimization was carried out using MMX (PC Model Serena Software (1993). Molecular modeling was performed using standard constants, and the dielectric constant was maintained at 1.5.

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Acknowledgements

We thank DST, Government of India for providing facilities in the department under DST FIST program. TS thanks CSIR, Government of India for a fellowship.

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  1. Department of Chemistry, University of Kalyani, Kalyani, Nadia, 741235, India

    Kumaresh Ghosh & Tanushree Sen

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  1. Kumaresh Ghosh
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  2. Tanushree Sen
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Correspondence to Kumaresh Ghosh.

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Ghosh, K., Sen, T. Naphthyridine-based receptors for flurometric detection of urea and biotin. J Incl Phenom Macrocycl Chem 67, 271–280 (2010). https://doi.org/10.1007/s10847-009-9707-6

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