Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development
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To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the CHildhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children with high versus low frequency GI symptoms. Compared to TD children, those with ASD [aOR 7.92 (4.89–12.85)] and DD [aOR 4.55 (2.51–8.24)] were more likely to have at least one frequent GI symptom. Restricting to ASD children, those with frequent abdominal pain, gaseousness, diarrhea, constipation or pain on stooling scored worse on irritability, social withdrawal, stereotypy, and hyperactivity compared with children having no frequent GI symptoms. Frequent GI problems affect young children with ASD and DD more commonly than those with TD. Maladaptive behaviors correlate with GI problems, suggesting these comorbidities require attention.
- Aman, M. G., & Singh, N. N. (1994). Aberrant behavior checklist-community. East Aurora, NY: Supplementary Manual.
- Buie, T., Campbell, D. B., Fuchs, G. J, 3rd, Furuta, G. T., Levy, J., Vandewater, J., et al. (2010a). Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics, 125(Suppl 1), S1–S18. CrossRef
- Buie, T., Fuchs, G. J, 3rd, Furuta, G. T., Furuta, G. T., Kooros, K., Levy, J., et al. (2010b). Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics, 125(Suppl 1), S19–S29. CrossRef
- De Theije, C. G., Wu, J., da Silva, S. L., Kamphuis, P. J., Garssen, J., Korte, S. M., et al. (2011). Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management. European Journal of Pharmacology, 666(S1), S70–s80. doi:10.1016/j.ejphar.2011.07.013. CrossRef
- Gorrindo, P., Williams, K. C., Lee, E. B., Walker, L. S., McGrew, S. G., & Levitt, P. (2012). Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Research, 5(2), 101–108. CrossRef
- Herndon, A. C., DiGuiseppi, C., Johnson, S. L., Leiferman, J., & Reynolds, A. (2009). Does nutritional intake differ between children with autism spectrum disorders and children with typical development? Journal of Autism and Developmental Disorders, 39(2), 212–222. CrossRef
- Hertz-Picciotto I, Croen L, Hansen R, Jones C, Pessah IN (2006). The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives, 114(7), 1119–1125. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513329/pdf/ehp0114-001119.pdf.
- Ibrahim, S. H., Voigt, R. G., Katusic, S. K., Weaver, A. L., & Barbaresi, W. J. (2009). Incidence of gastrointestinal symptoms in children with autism: a population-based study. Pediatrics, 124(2), 680–686. CrossRef
- Jyonouchi, H., Geng, L., Ruby, A., Reddy, C., & Zimmerman-Bier, B. (2005). Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. Journal of Pediatrics, 146(5), 605–610. CrossRef
- Le Couteur A, Lord C, Rutter M. (1993). The Autism Diagnostic Interview, Revised (ADI-R), Los Angeles, CA.
- Lord C, Rutter M, diLavore PC, Risi S. (2003). Autism Diagnostic Observation Schedule Manual, Los Angeles, CA.
- Maenner, M. J., Arneson, C. L., Levy, S. E., Kirby, R. S., Nicholas, J. S., & Durkin, M. S. (2012). Brief Report: Association between behavioral features and gastrointestinal problems among children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 42, 1520–1525. CrossRef
- Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171. CrossRef
- Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Services.
- Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G., et al. (2009). Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 39(3), 405–413. CrossRef
- Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Braun, K. V., et al. (2012). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33(2), 467–476. CrossRef
- Sparrow, S. S. (1984). Vineland adaptive behavior scales survey form manual. Circle Pines, MN: American Guidelines Service.
- Valicenti-McDermott, M., McVicar, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S128–S136. CrossRef
- Wang, L. W., Tancredi, D. J., & Thomas, D. W. (2011). The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Journal of Developmental and Behavioral Pediatrics, 32(5), 351–360. CrossRef
- Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development
Journal of Autism and Developmental Disorders
Volume 44, Issue 5 , pp 1117-1127
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- Print ISSN
- Online ISSN
- Springer US
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- Gastrointestinal problems
- Developmental delays
- Maladaptive behaviors
- Industry Sectors
- Author Affiliations
- 1. Department of Public Health Sciences, University of California, Davis, 1616 DaVinci Ct, Davis, CA, 95618, USA
- 2. UC CalFresh Nutrition Education Program, State Office, University of California, Davis, 1103 Meyer Hall, Davis, CA, 95616, USA
- 3. Department of Pediatrics, School of Medicine, University of California, Davis, Davis, CA, USA
- 4. Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Davis, CA, 95616, USA
- 5. Division of Environmental and Occupational Health, Department of Public Health Sciences, University of California, Davis, Davis, CA, USA