Abstract
Between 2006 and 2010, two research-validated instruments, Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) were filled out online by 4,188 mothers of Autism Spectrum Disorder (ASD) children, aged 4–21, as part of voluntary parental participation in a large web-based registry. Univariate and multivariate linear regression analysis (adjusted for child’s sex, ability to verbalize, categorical IQ score, and fetal growth rate) demonstrated significantly higher SCQ and SRS scores for ASD children of both preterm (<37 weeks) and post-term (>42 weeks) gestational age (GA) compared to ASD children of normal GA, thus indicating that both preterm and post-term children manifest increased ASD symptomatology. Normal GA at birth appears to mitigate the severity of autistic social impairment in ASD children.
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Acknowledgments
This project was funded by the National Institutes of Health (NIH) T32 Training Program in Perinatal Epidemiology at Michigan State University (MSU), grant number 2T32HD046377. We would like to thank the Interactive Autism Network (IAN) of the Kennedy Krieger Institute, Baltimore, MD for providing us with the data for this project.
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Movsas, T.Z., Paneth, N. The Effect of Gestational Age on Symptom Severity in Children with Autism Spectrum Disorder. J Autism Dev Disord 42, 2431–2439 (2012). https://doi.org/10.1007/s10803-012-1501-4
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DOI: https://doi.org/10.1007/s10803-012-1501-4