Brief Report

Journal of Autism and Developmental Disorders

, Volume 40, Issue 9, pp 1139-1145

First online:

Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder

  • Kenneth D. GadowAffiliated withDepartment of Psychiatry, Stony Brook UniversityDepartment of Psychiatry, Stony Brook University Email author 
  • , Jasmin RoohiAffiliated withDepartment of Genetics, Stony Brook University
  • , Carla J. DeVincentAffiliated withDepartment of Pediatrics, Stony Brook University
  • , Sarah KirschAffiliated withDepartment of Pathology, Stony Brook University
  • , Eli HatchwellAffiliated withDepartment of Pathology, Stony Brook University

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Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.


Autism Autism spectrum disorder SLC1A1 Obsessive–compulsive behaviors Separation anxiety Generalized anxiety