Brief Report: Autistic Traits in Twins Vs. Non-Twins—A Preliminary Study
Cite this article as: Ho, A., Todd, R.D. & Constantino, J.N. J Autism Dev Disord (2005) 35: 129. doi:10.1007/s10803-004-1040-8 Abstract
Previous studies have suggested that among affected sib pairs with autism there is an increase in the frequency of twins over what would be expected in comparison to the prevalence of twins in the general population. In this study we sought to determine whether
sub-threshold autistic traits were more pronounced in twins than in non-twins. The Social Responsiveness Scale (SRS) was administered in an epidemiologic twin sample ( n=802) and in a separate population-based sample of non-twins ascertained from a local school district ( n=255). For males (but not females), the mean SRS score was significantly higher among twins than among non-twins. As has been suggested for autism, twin status may incur increased liability to sub-threshold autistic symptomatology, particularly in males. Keywords autism twins SRS population genetics PDD-NOS References Betancur, C., Leboyer, M., Gillberg, C. 2002 Increased rate of twins with autism American Journal of Human Genetics 70 1381 1383 Google Scholar Chakrabarti, S., Fombonne, E. 2001 Pervasive developmental disorders in preschool children JAMA 285 3093 3099 CrossRef PubMed Google Scholar Constantino, J. N. 2005The social responsiveness scale Western Psychological Services Los Angeles Google Scholar
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