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Effect of bisphosphonates treatment on cytokine imbalance between TH17 and Treg in osteoporosis

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Abstract

Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T cells (Tregs) is suggested to contribute to the pathogenesis of osteoporosis. Broken TH17/Treg balance has been reported contributing to several inflammatory diseases. Although bisphosphonates are well-recognized inhibitors of osteoclastic activity, there is no serious examination of their effect on T cell subset (TH1/TH2/TH17/Treg) balances. Patients were categorized into 20 osteopenic and 20 osteoporotic patients treated with bisphosphonates for 1 year. We studied plasma levels of interleukins 4 (IL-4), IL-6, IL-10, IL-12, IL-17, IL-23, and interferon-gamma (IFN-γ), and transforming growth factor-beta (TGF-β) and their interrelations and correlation with osteoporosis treatment were evaluated. Treated osteoporotic patients have a significant reduction of plasma IL-6 (p < 0.05), IL-17 (p < 0.05), IL-23 (p < 0.05), and IFN-γ (p < 0.05), a significant increase in IL-4 (p < 0.05), IL-10 (p < 0.05), and TGF-β (p < 0.001), and comparable IL-12 levels as compared to controls. In conclusion, the significant reduction of Th17 cell cytokine cascade (IL-6, IL-17, and IL-23) and elevation of Treg cytokine cascade (IL-10 and TGF-β) might be considered as a very important observation about the effect of bisphosphonates on TH17/Treg imbalance in osteoporosis.

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Authors and Affiliations

  1. Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City University, Sadat City, Egypt

    Roba M. Talaat & Asmaa Sidek

  2. Department of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Assuit, Egypt

    Ahmed Mosalem

  3. Department of Orthopedics, Faculty of Medicine, El-Kasr El-Aini Hospital, Cairo University, Cairo, Egypt

    Ahmed Kholief

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  1. Roba M. Talaat
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  2. Asmaa Sidek
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  3. Ahmed Mosalem
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  4. Ahmed Kholief
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Correspondence to Roba M. Talaat.

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Talaat, R.M., Sidek, A., Mosalem, A. et al. Effect of bisphosphonates treatment on cytokine imbalance between TH17 and Treg in osteoporosis. Inflammopharmacol 23, 119–125 (2015). https://doi.org/10.1007/s10787-015-0233-4

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