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Mechanisms of Hemolysis During Sepsis

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Abstract

Cell-free hemoglobin is increasingly playing a more central role in the pathogenesis of sepsis being proved to be a potent predictor of patient’s outcome. It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis.

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Acknowledgements

This work is dedicated to Prof. Dr. Herbert de Groot who suddenly deceased at the age of 65 years.

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  1. Institute of Physiological Chemistry, University Hospital Essen, Hufelandstraße 55, D-45122, Essen, Germany

    Katharina Effenberger-Neidnicht

  2. Department of Anesthesiology and Intensive Care, University Hospital Essen, Essen, Germany

    Matthias Hartmann

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Correspondence to Katharina Effenberger-Neidnicht.

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Effenberger-Neidnicht, K., Hartmann, M. Mechanisms of Hemolysis During Sepsis. Inflammation 41, 1569–1581 (2018). https://doi.org/10.1007/s10753-018-0810-y

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