The hazards of death by smoking in middle-aged women
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- Gram, I.T., Sandin, S., Braaten, T. et al. Eur J Epidemiol (2013) 28: 799. doi:10.1007/s10654-013-9851-6
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Recent studies have found that the risk of death continues to increase among female smokers, as compared with women who have never smoked. We wanted to examine the effect of smoking on all-cause and cause-specific mortality and calculate the corresponding population attributable fraction (PAF) of mortality in the Norwegian women and cancer study; a nationally representative prospective cohort study. We followed 85,320 women, aged 31–70 years, who completed a questionnaire in 1991–1997, through linkages to national registries through December 2008. Questionnaire data included information on lifestyle factors, including lifetime history of smoking. Poisson regression models were fitted to estimate relative risks (RRs) with 95 % confidence intervals (CIs) adjusting for age, birth cohort, education, postmenopausal status, alcohol consumption and body mass index, all at enrollment. During a mean follow-up time of 14 years 2,842 deaths occurred. Compared with that of never smokers, current smokers had a mortality rate that was double (RR = 2.34; 95 % CI 2.13–2.62) from deaths overall, triple (RR = 3.30; 95 % CI 2.21–4.82) from cerebrovascular disease and myocardial infarction (RR = 3.65; 95 % CI 2.18–6.15), 12 times (RR = 12.16; 95 % CI 7.80–19.00) from lung cancer and seventeen times (RR = 17.00; 95 % CI 5.90–48.78) from chronic obstructive pulmonary diseases. The PAF of mortality due to smoking was 34 % (CI 30–39). In summary, one in three deaths among middle aged women in Norway could have been prevented if the women did not smoke. More middle-aged women, than ever before, are dying prematurely due to smoking in Norway.
KeywordsSmokingCause-specific mortalityPopulation attributable fractionNOWAC studyNorwayWomen
Population attributable fraction
- NOWAC study
Norwegian women and cancer study
International Agency for Research on Cancer
Body mass index
Chronic obstructive pulmonary disease
International classification of diseases
Worldwide, tobacco use causes annually more than five million deaths, or one death every 6 seconds. Unless current smokers stop smoking before or during middle age, this number is expected to rise to eight million or more by the year 2030 [1–3]. In spite of the overwhelming evidence of the detrimental effects of smoking on health [4, 5], the tobacco use among women is rising globally and the age of initiation of daily smoking among women seems to have become as young as it is in men [6, 7].
For women in Norway, the prevalence of daily smokers was 23 % in 1954, the peak was at 37 % in 1970 and then it stabilized at around 32 % for the rest of the century . The decline among female smokers first started in the twentyfirst century . As a consequence the lung cancer incidence and mortality rates have both been increasing for Norwegian women. In fact, the strongest increase in cancer incidence from the past 5-year period (2001–2005) until the current one (2006–2010) occurred in lung cancer (16%) . The four tobacco epidemic stages model suggested by Lopez et al. almost 20 years ago described the effects on mortality of the cigarette epidemic in Western countries such as the USA, UK and Australia. The rise and fall in female smoking and in smoking-attributed mortality usually lagged behind that in men by about 20–30 years .
Recent studies have found that for women the risk of death from cigarette smoking continues to increase resulting in a population attributable fraction (PAF) of mortality that is larger than previously reported [4, 12–15].
As pointed out by Oza et al. , estimating the number of deaths attributable to smoking is needed for priority setting and monitoring the disease burden associated with this risk factor in different populations.
Today, the majority of middle-aged Norwegian women are either former or current smokers, who started to smoke in their teens . We wanted to estimate the effects of cigarette smoking on all-cause and cause-specific mortality and estimate the proportion of deaths attributable to smoking in the Norwegian Women and Cancer (NOWAC) study, a nationally representative prospective cohort study.
Materials and methods
The NOWAC study is a nationally representative prospective cohort study comprising a sample of the Norwegian middle-aged female population. The cohort profile has been previously described in detail [18, 19]. Briefly, a random sample of women was selected from the central population register according to year of birth. These women were sent a letter of invitation to participate in the study, which also contained a questionnaire, and a pre-stamped return envelope. The National Data Inspectorate and the Regional Committee for Medical Research Ethics approved the study. All women gave an informed consent (http://site.uit.no/kvinnerogkreft).
The inclusion criteria for the present study were women born from 1926 to 1965, who during 1991–1997 completed an initial questionnaire, containing questions on life style factors as smoking and alcohol consumption (N = 95,947). The overall response rate was 57 %. Women who emigrated or died (N = 22) before the start of follow-up were excluded. We excluded 10,605 women due to missing information on either smoking status (N = 2,224) or any of the co-variables (education, BMI, menopausal status and alcohol consumption) under study. Altogether 458 women with missing information had died during follow-up of which 64 (14 %) had missing information on smoking status. The analytical cohort comprised the remaining 85,320 women with complete information in the multivariable analyses. Compared with the women in the analytical cohort, the women that were excluded due to missing information were on average 2.7 years older, but were similar according to education, BMI and alcohol consumption (data not shown).
The baseline questionnaire included a detailed assessment of lifetime smoking history. The questionnaires asked if the women had ever smoked, and those answering “yes” were asked the number of cigarettes smoked daily at different ages. Subsequently, they were asked if they currently smoked on a daily basis. We categorized ever smokers according to current and former smoking status at enrollment. All women who were neither current nor former daily smokers were classified as never smokers. The baseline questionnaires also asked about years of education, height and current weight (allowing us to calculate body mass index, BMI, kg/m2), menopausal status (pre-, peri-, postmenopausal), postmenopausal hormone therapy (yes, no), hysterectomy (yes, no), including alcohol consumption, all at enrollment. We calculated average consumption of alcohol in g/day based on the content of pure alcohol in different sorts of beverages and usual portion sizes in Norway among drinkers. Women who reported to be teetotalers and those answering “seldom” or “never” had their alcohol consumption set to zero.
Follow-up and endpoints
We followed the women through linkages to the Norwegian Central Population Register, utilizing the unique national birth number to identify all cases of deaths and emigrations. The end point in our study was death from any cause during follow-up, which ended December 31st, 2008. All causes of death were coded according to the original codes in the International Classification of Diseases, Ninth Revision (ICD-9) before 1996 and the original codes of the ICD-10 from 1996 and after. The deaths were classified into three main outcome categories: death from cancer (C00–C97), cardio-vascular diseases (CVDs) (I00–I99), respiratory diseases (J00–J99). The other deaths were collapsed in one group.
Cancer deaths were further classified into: (1) lung cancer (C34), (2) other smoking-related cancers , which included oral cavity (C00–C08), oropharynx (C09, C10, C12–C14), nasopharynx (C11), esophagus (C15), stomach (C16), colorectal (C18–C21), liver (C22), pancreas (C25), nasal cavity and sinuses (C30, C31), larynx (C32), uterine cervix (C53), kidney (C64), lower urinary tract (C65–C68) and myeloid leukemia (C42) and (3) remaining cancers not established to be smoking-related . Deaths from CVDs and respiratory diseases were further classified into: (1) myocardial infarction (MI), (I21–I22), (2) cerebrovascular diseases (I60–I69), (3) remaining circulatory diseases and (1) COPD (J40–J44), (2) remaining respiratory diseases, respectively.
We used Poisson regression models (with attained age between cohort entry and exit as the underlying time variable) to obtain adjusted relative risks (RRs) with two-sided 95 % Wald confidence intervals (CI) that compared categories of smokers (current, former, ever) with never smokers treated as a fixed reference group. We fitted regression models by splitting the follow-up-time into 1-year intervals . Risk time was counted from date of enrolment until censoring due to death, emigration or end of follow-up (December 31st, 2008), whichever occurred first. We estimated the age- and multivariable adjusted association between smoking status at enrolment and mortality overall and for 11 selected categories of disease outcome.
We included the following variables; years of education (<10,10–12, ≥13), BMI (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), menopausal status (pre-, peri-, postmenopausal, postmenopausal hormone therapy, hysterectomy), alcohol consumption (0, >0–4, ≥5 g/day) all at enrolment, and birth cohort (1927–1936,1937–1946,1947–1956, 1957–1965), decided a priori, for potential confounding the smoking and mortality association.
Altogether 2,842 deaths occurred during the approximately 1.2 million woman-years of observation with a mean follow-up time of 14 years. Among the deaths, 1,800 (63 %) were due to cancer, 426 (15 %) due to CVD, 108 (4 %) due to respiratory diseases and 508 (18 %) to remaining causes. Overall, 65 % (n = 55,227) of the women reported to be ever (35 % current and 30 % former) smokers.
Distribution of selected characteristics given as mean (SD)a and percentages (%) according to smoking status, all at enrollment, Norwegian Women and Cancer (NOWAC) Study 1991–2008, (N = 85,320)
Age at enrollment (years)a
Age at cohort exit (years)a
Person years of follow-upa
BMI at enrollmenta
Alcohol consumption (g/day)b
Compared with never smokers, former smokers had a 34 % (RR = 1.34; 95 % CI 1.21–1.49) and current smokers a more than double (RR = 2.34; 95 % CI 2.13–2.62) overall mortality rate.
Age- and multivariablea adjusted overall and selected cause-specific relative risk (RR) of mortality according to smoking status at enrollment, Norwegian Women and Cancer (NOWAC) Study 1991–2008 (N = 85,320)
n = 30,093
n = 25,309
n = 29,918
95 % CI
95 % CI
Cases (N = 2842)
Three main outcome categories
Cases (N = 1800)
Total cardiovascular diseases
Cases (N = 426)
Total respiratory diseases
Cases (N = 108)
Selected cause-specific categories
Cases (N = 298)
Other smoking-related cancersb
Cases (N = 764)
Cases (N = 738)
Cases (N = 141)
Cases (N = 103)
Cases (N = 182)
Chronic obstructive pulmonary diseases
Cases (N = 68)
Other respiratory diseases
Cases (N = 40)
Overall and selected cause-specific mortalitya among ever compared with never smokers at enrollment, and the population attributable fraction (PAF) (%) of smoking with confidence intervals (CI), Norwegian Women and Cancer (NOWAC) Study, 1991–2008 (N = 85,320)
n = 30,093
n = 55,227
Three main outcome categories
Total cardiovascular disease
Total respiratory diseases
Selected cause-specific categories
Chronic obstructive pulmonary diseases
Other respiratory diseases
Our study shows that compared with never smokers, both former and current smokers at cohort enrollment in the 1990s have an increased risk of dying overall, as well as dying from the three main outcome categories; total cancer, total CVD and total respiratory diseases. The increased risk was more pronounced for current than for former smokers indicating the effects of quitting smoking. One in three deaths in this female population may be attributed to smoking and could have been avoided if the women did not smoke.
As we do, recent studies [13–15, 22–27], including Caucasian women born in the 1940’s or later, found a more than doubling in the all-cause mortality rate, when comparing current with never smokers. Corresponding figures have for the first time emerged among Japanese women .
In our study, except for cancers not established to be smoking-related , current smoking was associated with an significantly increased risk of mortality from all categories of cause-specific mortality examined (lung cancer, other smoking-related cancers, circulatory diseases, MI, cerebrovascular diseases, COBP, and other respiratory diseases).
We find a three-fold mortality rate among current smokers compared with that of never smokers for cerebrovascular diseases and MI, similar to those displayed in the Nurses’ Health study ; and in the Million Women Study , while our mortality rate from COPD and from lung cancer was much lower than in the other two studies. The US study , had more than 12,000 deaths during a follow-up time of 24 years, while the UK study , had 66,000 deaths after 12 years. Both studies  had a RR of mortality from lung cancer of more than 20, while the mortality rate from COPD was 40 and 35, respectively. We expect that the deaths related to lung cancer and COPD, which have a long natural history, will increase when we have a longer follow-up time. Also, Kenfield et al.  showed in a later follow-up study that exposure assessed only at enrollment, underestimated the mortality risk due to smoking, compared with a second assessment during follow-up, especially for COPD and lung cancer.
The PAF of mortality due to smoking among Norwegian women has previously been estimated to be less than 20 % when mortality rates from lung cancer were used as an indirect measure of cigarette smoking [4, 12, 29], when cohort studies from the mid-70 s were used  and when the smoking prevalence surveys published by the Norwegian Central Bureau of Statistics were used [8, 30] Thun et al. , estimated that in 2009, the PAF of mortality due to smoking was highest (26–30 %) among women aged 35–69 years, in The Netherlands, Denmark, Hungary and Canada. In our study, based on individual data on both exposure and outcome, the corresponding PAF was estimated to be 34 % in Norway in 2008, with the upper limit of the 95 % CI as high as 39 %.
The life expectancy for Norwegian females was more than 83 years in 2008 . The low background mortality rate for women, which is the denominator of our RRs, leads to greater PAF’s of mortality due to smoking. Our finding of a high proportion of deaths that could have been avoided if nobody was smoking is in accordance with the rapidly increasing lung cancer incidence for Norwegian women. The age adjusted world lung cancer incidence rate more than doubled from 11.7 per 100,000 person-years in the 5-year period (1986–1990) immediately before the commencement of our study to 25.1 per 100,000 person-years for the current 5 year period including the year which our follow-up ended . This increasing lung cancer incidence also tells us that the PAF of mortality due to smoking among Norwegian women has not peaked yet.
As pointed out by Jha , the full effects of smoking can take 50 years to measure in individuals, and up to 100 years to measure in populations. Our study shows the PAF due to smoking among females already to be higher than the peak in the gender specific model recently developed by Thun et al. .
The most important strength of our study is that it is a nationally representative prospective cohort study allowing us to calculate the PAF of mortality due to smoking for middle-aged women. We know from our previous studies that the smoking exposure [17, 32, 33] and the cancer incidence  reflect known smoking patterns [8, 9] and cancer incidence  for Norwegian women. Thus, we are confident that our cohort is representative of the Norwegian female population, born between 1926 and 1965, both according to exposure and outcome of this study.
Other major strengths of our study are; we have a high proportion of both current and former smokers, virtually complete follow-up through the National population based registries and the possibility of examining the association with smoking according to both all-cause and cause-specific mortality. Another force is that we focus our PAF estimates on the comparison between ever versus never smokers. Thus, it is only never smokers that could possibly change smoking status during follow-up. Since very few Norwegians start to smoke after the age of 30 and the mean age at enrolment for our study is more than 40 years, we are confident that the possible changes in smoking status among the never smokers during follow-up did not influence our PAF estimates. Furthermore, we have detailed information on, and were able to control for alcohol consumption and BMI, which are established risk factors for mortality.
One major limitation of this report is that we have a limited number of deaths. Furthermore, 9 % of the women had missing values for physical activity levels and therefore this variable was not included in the multivariable analyses as there was no difference in physical activity levels according to smoking status. As in our study, neither of the seven [13–15, 25, 26, 34, 35] recently published studies did find much effect of confounding when they compared the effect of smoking on mortality. Five of these studies were conducted in the US [14, 15, 25, 26, 34]; one in the UK , and one in China . We found a small non-significantly increased risk of deaths from cancers not established to be associated with smoking. This may be due to chance or that breast cancer should be in the category for smoking-related cancers. According to the most recent IARC monograph cigarette smoking is possibly carcinogenic to the human breast . After this monograph was published two large cohort studies, one from the US , and our own Norwegian study  based on more than 300,000 women, conclude that smoking initiation before the first childbirth increase the risk of breast cancer.
Other limitations are that we have not validated self-reported information on height and body weight and that the current PAF formula does not provide a fully adjusted estimate of PAF due to lack of adjustment of the prevalence. We chose not to exclude women with prevalent disease as a previous study from the same cohort which examined physical activity and mortality found basically the same results when they did their analyses with and without women with prevalent disease at enrolment . This has most likely deflated or RR estimates of mortality. Given the reduction in life expectancy associated with smoking we cannot rule out that part of the cause-specific associations is hidden or obscured by the competing causes of death with increasing age. We do not expect that the changes in BMI or alcohol consumption during follow-up would influence our results to any great extent. Nevertheless, we cannot rule out the possibility of residual confounding due to the above described factors, or other factors we did not measure.
In summary, one in three deaths among middle aged women in Norway could have been prevented if the women did not smoke. More middle-aged women, than ever before, are dying prematurely due to smoking in Norway.
This work was carried out at the University of Tromsø and while Professor Gram was a Visiting Scholar at the Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. No funding was received for this study. The authors declare that they have no conflict of interest in relation to this manuscript. Last, but not least, we want to thank all the women participating in the Norwegian women and cancer study.
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