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Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2)

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Abstract

The major polyphenols in green tea, (−)-epigallocatechin and (−)-epigallocatechin gallate, have been shown to enhance the phagocytic activity of macrophage-like cells; however, the mechanism involved was not clarified. In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.

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Acknowledgments

This work was supported by a grant for project research (Development of fundamental technology for analysis and evaluation of functional agricultural products and functional foods), Ministry of Agriculture, Fishery and Forestry, Japan.

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Authors and Affiliations

  1. NARO Institute of Vegetable and Tes Science, 2769 Kanaya-Shishidoi, Shimada, Shizuoka, 428-8501, Japan

    Manami Monobe, Kaori Ema & Yoshiko Tokuda

  2. NARO National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan

    Mari Maeda-Yamamoto

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  1. Manami Monobe
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  2. Kaori Ema
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  3. Yoshiko Tokuda
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  4. Mari Maeda-Yamamoto
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Correspondence to Manami Monobe.

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Monobe, M., Ema, K., Tokuda, Y. et al. Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2). Cytotechnology 66, 561–566 (2014). https://doi.org/10.1007/s10616-013-9618-7

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  • DOI: https://doi.org/10.1007/s10616-013-9618-7

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