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Modified coumarins. 27. Ssynthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins

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Abstract

Amides of 5,7-dihydroxy-4-methylcoumaryl-3-ylacetic acid were synthesized by the activated ester method using N-hydroxysuccinimide and diisopropylcarbodiimide or by reaction with N,N-carbonylimidazole. The reactivity of 3-substituted 5,7-dihydroxy-4-methylcoumarins toward 2,2-diphenyl-1-picrylhydrazyl and superoxide radical was analyzed. The effect of the synthesized compounds on xanthineoxidase activity was studied.

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Authors and Affiliations

  1. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, 02094, Ukraine, Kiev, ul. Murmanskaya

    M. M. Garazd, O. V. Muzychka, A. I. Vovk, I. V. Nagorichna & A. S. Ogorodniichuk

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  1. M. M. Garazd
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  2. O. V. Muzychka
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  3. A. I. Vovk
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  4. I. V. Nagorichna
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  5. A. S. Ogorodniichuk
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 18–21, January–February, 2007.

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Garazd, M.M., Muzychka, O.V., Vovk, A.I. et al. Modified coumarins. 27. Ssynthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins. Chem Nat Compd 43, 19–23 (2007). https://doi.org/10.1007/s10600-007-0055-8

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  • DOI: https://doi.org/10.1007/s10600-007-0055-8

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