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Alkylation of 2-(2,4-dichlorophenyl)-3-cyano-6-methyl-4-(1H-1,2,4-triazol-1-yl)methylpyridine at the methylene group

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Chemistry of Heterocyclic Compounds Aims and scope

The reactivity of the 1-triazolyl- and 1-imidazolyl-substituted methylene groups at position 4 of pyridine ring toward alkyl halides is described. Nitrogen heterocycles attached to the methylene group, as well as a 3-cyano group effectively promoted the alkylation, offering a convenient method for constructing structurally diverse molecules that may present pharmaceutical interest.

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This work was supported by the Shanghai Committee of Science & Technology (Project No. 13ZR1461600 and 13431900202).

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Authors and Affiliations

  1. State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, State Institute of Pharmaceutical Industry, 285 Gebaini Lu, Shanghai, 201203, China

    Yan Zhu, Zhengyan Cai, Qun Hao & Weicheng Zhou

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  1. Yan Zhu
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  2. Zhengyan Cai
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  3. Qun Hao
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  4. Weicheng Zhou
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Correspondence to Weicheng Zhou.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(8), 564–569

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Zhu, Y., Cai, Z., Hao, Q. et al. Alkylation of 2-(2,4-dichlorophenyl)-3-cyano-6-methyl-4-(1H-1,2,4-triazol-1-yl)methylpyridine at the methylene group. Chem Heterocycl Comp 52, 564–569 (2016). https://doi.org/10.1007/s10593-016-1932-5

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  • DOI: https://doi.org/10.1007/s10593-016-1932-5

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