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Synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines

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Abstract

An efficient method for the synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines by the ring transformation in the corresponding pyrimidines was developed. Further modification of the pyridines obtained under conditions of a room temperature aerobic Suzuki reaction in the presence of trans-bis(dicyclohexylamine)palladium(II) acetate as a catalyst was studied

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620041, Ekaterinburg, Russian Federation

    E. V. Verbitskiy, E. M. Cheprakova, M. G. Pervova, G. L. Rusinov, O. N. Chupakhin & V. N. Charushin

  2. Ural Federal University named after the first president of Russia B. N. Eltsin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    E. V. Verbitskiy, E. M. Cheprakova, G. L. Rusinov, O. N. Chupakhin & V. N. Charushin

  3. Russian-Armenian (Slavonic) University, 123 ul. O. Emmina, 0051, Yerevan, Republic of Armenia

    G. G. Danagulyan

  4. Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 prosp. Azatutyan, 0014, Yerevan, Republic of Armenia

    G. G. Danagulyan

Authors
  1. E. V. Verbitskiy
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  2. E. M. Cheprakova
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  3. M. G. Pervova
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  4. G. G. Danagulyan
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  5. G. L. Rusinov
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  6. O. N. Chupakhin
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  7. V. N. Charushin
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Corresponding author

Correspondence to E. V. Verbitskiy.

Additional information

Dedicated to Academician of the Russian Academy of Sciences V. I. Minkin on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0689—0694, March, 2015.

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Verbitskiy, E.V., Cheprakova, E.M., Pervova, M.G. et al. Synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines. Russ Chem Bull 64, 689–694 (2015). https://doi.org/10.1007/s11172-015-0920-8

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  • DOI: https://doi.org/10.1007/s11172-015-0920-8

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