We studied the condensation of 1,2-diamino-4-phenylimidazole with N-arylmaleimides and established that this reaction occurred upon brief refluxing of reactants in isopropanol in the presence of a catalytic amount of acetic acid and produced substituted 7-amino-N-aryl-2-oxo-5-phenyl-1,2,3,4-tetrahydroimidazo[1,5-b]pyridazine-4-carboxamides. Performing this reaction at room temperature led to the acyclic intermediates N-aryl-3-(1,2-diamino-4-phenylimidazol-5-yl)pyrrolidine-2,5-diones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(9), 829–833
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Vandyshev, D.Y., Shikhaliev, K.S., Potapov, A.Y. et al. Condensation of 1,2-diamino-4-phenylimidazole and N-arylmaleimides with the formation of new tetrahydroimidazo[1,5-b]pyridazines. Chem Heterocycl Comp 51, 829–833 (2015). https://doi.org/10.1007/s10593-015-1782-6
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DOI: https://doi.org/10.1007/s10593-015-1782-6