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Mannich reaction in the synthesis of N,S-containing heterocycles. 13*. One-pot method for preparing pyrimido[4,3-b]-[1,3,5]thiadiazines by reaction of aldehydes, cyanothioacetamide, formaldehyde, and primary amines

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Chemistry of Heterocyclic Compounds Aims and scope

Successive reaction of cyanothioacetamide with aliphatic or aromatic aldehydes, formaldehyde, and primary amines gives the corresponding 3,7-disubstituted 3,4,7,8-tetrahydro-2H,6H-pyrimido-[4,3-b][1,3,5]thiadiazine-9-carbonitriles.

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Authors and Affiliations

  1. “ChemEx Laboratory”, Vladimir Dal’ East-Ukrainian National University, 20-A/7 Molodezhny Kv., Lugansk, 91034, Ukraine

    V. V. Dotsenko, K. A. Frolov & S. G. Krivokolysko

Authors
  1. V. V. Dotsenko
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  2. K. A. Frolov
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  3. S. G. Krivokolysko
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Correspondence to V. V. Dotsenko.

Additional information

*For Communication 12, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 689-697, April, 2012.

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Dotsenko, V.V., Frolov, K.A. & Krivokolysko, S.G. Mannich reaction in the synthesis of N,S-containing heterocycles. 13*. One-pot method for preparing pyrimido[4,3-b]-[1,3,5]thiadiazines by reaction of aldehydes, cyanothioacetamide, formaldehyde, and primary amines. Chem Heterocycl Comp 48, 642–649 (2012). https://doi.org/10.1007/s10593-012-1038-7

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