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Substituted quinolinones 15*. Preparation and enzymatic activity of some pyrazoloazines linked to the 4-hydroxy-1-methyl- quinolin-2(1H)-one moiety

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Chemistry of Heterocyclic Compounds Aims and scope

The heterocyclization reaction of pyrazolinylquinolinone and its 4-chlorobenzylidene, 2-pyridylmethylene, pyridylaminomethylene, and 2-pyridylhydrazone derivatives with some active methylene nitriles and acrylonitriles, is described. These cyclization reactions afforded novel heterocyclic systems, such as pyrazolo[3,4-b]pyridines, pyrano[2,3-c]pyrazoles, and pyrazolo[4,3-c]pyridazines, linked to position 3 of 4-hydroxy-1-methylquinolin-2(1H)-one. The effect of the new products on the activity of α-amylase was examined. Some pyrano[2,3-c]pyrazoles revealed significant increase in α-D-glucose production by the enzyme.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt

    A. Khodairy

  2. Department of Chemistry, Faculty of Education, Ain Shams University, Cairo, 11757, Egypt

    M. Abass

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  1. A. Khodairy
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  2. M. Abass
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Correspondence to A. Khodairy.

Additional information

* For Communication 14, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 736–749, May, 2011.

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Khodairy, A., Abass, M. Substituted quinolinones 15*. Preparation and enzymatic activity of some pyrazoloazines linked to the 4-hydroxy-1-methyl- quinolin-2(1H)-one moiety. Chem Heterocycl Comp 47, 611–621 (2011). https://doi.org/10.1007/s10593-011-0806-0

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  • DOI: https://doi.org/10.1007/s10593-011-0806-0

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