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Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum

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Abstract

The insulin and insulin-like growth factor-1 (IGF-1) are considered to play important roles in brain development; and their cognate receptors -InsR and IGF-1R- localized within distinct brain regions including cerebellum. Using Real-Time PCR and western blot analysis, we compared the expression of InsR and IGF-1R in male and female developing rat cerebellum at P0, P7, and P14. At all time points studied, the cerebellar expression of IGF-1R, both at mRNA and protein levels was higher than that of InsR. The lowest InsR and IGF-1R mRNA and protein levels were measured in the neonate cerebellum, independent of gender. In males, the highest InsR and IGF-1R mRNA and protein expression were found at P7. InsR and IGF-1R expression increased significantly between P0 and P7, followed by a marked downregulation at P14. In contrast, in females, mRNA and protein levels of InsR and IGF-1R remain unchanged between P0 and P7, and are upregulated at P14. Therefore, peaked InsR and IGF-1R expression in female cerebelli occurred at P14. Interestingly, changes in mRNA expression and in protein levels followed the same developmental pattern, indicating that InsR and IGF-1R transcription is not subject to modulatory effects during the first 2 weeks of development. These findings indicate that there are prominent sexual differences in InsR and IGF-1R expression in the developing rat cerebellum, suggesting a probable mechanism for the control of gender differences in development and function of the cerebellum.

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Acknowledgments

This work was supported by a Mashhad University of Medical Sciences (MUMS) grant (No. 88631).

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Haghir

  2. Medical Genetics and Functional Genomics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Haghir

  3. Microbiology and Virology Research Center, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Abd-Al-Rahim Rezaee & Hossein Nomani

  4. Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mojtaba Sankian

  5. Hazrat Rasoul Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Hamed Kheradmand

  6. Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

    Javad Hami

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  1. Hossein Haghir
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Haghir, H., Rezaee, AAR., Nomani, H. et al. Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol 33, 369–377 (2013). https://doi.org/10.1007/s10571-012-9903-6

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