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Eicosanoid signaling in carcinogenesis of colorectal cancer

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Abstract

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the USA. It is of practical importance to identify novel therapeutic targets of CRC to develop new anti-cancer drugs and to discover novel biomarkers of CRC to develop new detection methods. Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid-signaling molecules involved in the regulation of inflammation and tumorigenesis. Substantial studies have shown that the profiles of eicosanoids are deregulated in CRC, and the enzymes, metabolites, and receptors in the eicosanoid signaling cascade play critical roles in regulating colonic inflammation and colon tumorigenesis. In this review, we discuss the roles of the COX, LOX, and CYP pathways in the carcinogenesis of CRC.

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Funding

We thank funding support from NIH/NCI R03CA218520 and USDA NIFA 2016-67017-24416.

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Authors and Affiliations

  1. College of Life Science, Northwest University, Xi’an, Shaanxi, China

    Yuxin Wang & Xinfeng Zhao

  2. Department of Food Science, University of Massachusetts, Amherst, MA, USA

    Yuxin Wang, Weicang Wang, Katherine Z. Sanidad & Guodong Zhang

  3. Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA

    Katherine Z. Sanidad & Guodong Zhang

  4. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA

    Pei-An Shih

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  1. Yuxin Wang
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Wang, Y., Wang, W., Sanidad, K.Z. et al. Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Rev 37, 257–267 (2018). https://doi.org/10.1007/s10555-018-9739-8

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