Article

Cancer and Metastasis Reviews

, Volume 29, Issue 3, pp 483-502

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

  • Limin ShuAffiliated withCenter for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey
  • , Ka-Lung CheungAffiliated withCenter for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey
  • , Tin Oo KhorAffiliated withCenter for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey
  • , Chi ChenAffiliated withDepartment of Food Science and Nutrition, The College of Food, Agriculture and Natural Resource Sciences, University of Minnesota, Twin Cities Email author 
  • , Ah-Ng KongAffiliated withCenter for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey Email author 

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Abstract

Carcinogenesis is a multi-step process which could be prevented by phytochemicals. Phytochemicals from dietary plants and other plant sources such as herbs are becoming increasingly important sources of anticancer drugs or compounds for cancer chemoprevention or adjuvant chemotherapy. Phytochemicals can prevent cancer initiation, promotion, and progression by exerting anti-inflammatory and anti-oxidative stress effects which are mediated by integrated Nrf2, NF-κB, and AP-1 signaling pathways. In addition, phytochemicals from herbal medicinal plants and/or some dietary plants developed in recent years have been shown to induce apoptosis in cancer cells and inhibition of tumor growth in vivo. In advanced tumors, a series of changes involving critical signaling molecules that would drive tumor cells undergoing epithelial–mesenchymal transition and becoming invasive. In this review, we will discuss the potential molecular targets and signaling pathways that mediate tumor onset and metastasis. In addition, we will shed light on some of the phytochemicals that are capable of targeting these signaling pathways which would make them potentially applicable to cancer chemoprevention, treatment and control of cancer progression.

Keywords

Phytochemicals Herbs Cancer chemoprevention Metastasis Molecular targets