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Intravascular cell-to-cell adhesive interactions and bone metastasis

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Abstract

Metastatic cancer spread to bones, causing intractable pain, pathological fractures, spinal cord compression, and ultimately death, represents massive clinical problem. Intravascular cell-to-cell heterotypic (between cancer and other types of cells) and homotypic (between cancer cells) adhesive interactions, leading to the establishment of metastatic deposits in bone marrow vasculature, represent important rate-limiting steps in bone metastasis. In this review, we discuss molecular and cellular mechanisms underpinning metastasis-associated intravascular cell-to-cell adhesive interactions, their role in a multi-step metastatic cascade, and a potential for therapeutic targeting of early metastasis-associated adhesive events.

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Acknowledgment

VVG is supported by the VA Merit Review Program.

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Authors and Affiliations

  1. Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO, 65201, USA

    Vladislav V. Glinsky

  2. Department of Biochemistry, University of Missouri, Columbia, MO, 65212, USA

    Vladislav V. Glinsky

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  1. Vladislav V. Glinsky
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Correspondence to Vladislav V. Glinsky.

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Glinsky, V.V. Intravascular cell-to-cell adhesive interactions and bone metastasis. Cancer Metastasis Rev 25, 531–540 (2006). https://doi.org/10.1007/s10555-006-9029-8

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  • DOI: https://doi.org/10.1007/s10555-006-9029-8

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