Biomedical Microdevices

, 11:1195

Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery

  • Chun Yan Jin
  • Man Hee Han
  • Seung S. Lee
  • Yo Han Choi
Article

DOI: 10.1007/s10544-009-9337-1

Cite this article as:
Jin, C.Y., Han, M.H., Lee, S.S. et al. Biomed Microdevices (2009) 11: 1195. doi:10.1007/s10544-009-9337-1

Abstract

The key issues in the development of a microneedle patch as a tool for transdermal drug delivery are safety and delivery performance in addition to economical production. In this paper, novel fabrication methods for an inexpensive microneedle patch made of biocompatible polymer are reported, along with functional verifications for the fabricated microneedle patch through animal models. We combined the merits of in-line microneedles, i.e., easy and economical production, with the superior performance of two-dimensionally arrayed microneedles. One-dimensionally fabricated microneedles were assembled to make two-dimensionally arrayed patches to attain our goal. First, we fabricated strips with one-dimensionally arrayed microneedles through deep X-ray lithography on polymethylmethacrylate or another negative photoresist, SU-8, with sharply reduced exposure time. Second, we assembled microneedle strips to make two-dimensionally arrayed microneedles, which we utilized further for fabrication of molding masters. Finally, we prepared microneedle patches made of polycarbonate by hot embossing with these masters. We then demonstrated the actual delivery of exogenous materials through application on skin via animal experiments, and we found no detectable side effects such as inflammation or allergic reactions at the site of application.

Keywords

MicroneedleTransdermal drug deliveryBiocompatibleDeep X-ray lithographyMolding

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Chun Yan Jin
    • 1
  • Man Hee Han
    • 1
  • Seung S. Lee
    • 1
  • Yo Han Choi
    • 2
  1. 1.Department of Mechanical EngineeringKorea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea
  2. 2.BioMEMS team, Electronics and Telecommunications Research InstituteDaejeonRepublic of Korea