Biology & Philosophy

, Volume 27, Issue 5, pp 705–721

Diagrams as locality aids for explanation and model construction in cell biology

Authors

    • Department of PhilosophyUniversity of Alabama in Huntsville
  • Olaf Wolkenhauer
    • Department of Systems Biology and BioinformaticsUniversity of Rostock
    • Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research CentreStellenbosch University
Article

DOI: 10.1007/s10539-012-9311-9

Cite this article as:
Jones, N. & Wolkenhauer, O. Biol Philos (2012) 27: 705. doi:10.1007/s10539-012-9311-9

Abstract

Using as case studies two early diagrams that represent mechanisms of the cell division cycle, we aim to extend prior philosophical analyses of the roles of diagrams in scientific reasoning, and specifically their role in biological reasoning. The diagrams we discuss are, in practice, integral and indispensible elements of reasoning from experimental data about the cell division cycle to mathematical models of the cycle’s molecular mechanisms. In accordance with prior analyses, the diagrams provide functional explanations of the cell cycle and facilitate the construction of mathematical models of the cell cycle. But, extending beyond those analyses, we show how diagrams facilitate the construction of mathematical models, and we argue that the diagrams permit nomological explanations of the cell cycle. We further argue that what makes diagrams integral and indispensible for explanation and model construction is their nature as locality aids: they group together information that is to be used together in a way that sentential representations do not.

Keywords

Cell biology Diagram Explanation Locality aid Model construction

Copyright information

© Springer Science+Business Media B.V. 2012