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Biocompatibility of NiTi alloys in the cell behaviour

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Abstract

Metallic biomaterial alloys composed of nickel and titanium have unique thermal shape memory, superelastic, and high damping properties, which are widely used in the medicine. The major parameter evaluated in the studies regarding the behaviour of the material in the contact with organism or cells is biocompatibility. The aim of the studies is to clarify the differences in the proliferation, growth, and morphology especially in the cell cultures. The cytotoxicity is affected among other by release of the metal ions in the presence of the metal alloy, which is further dependent on the possible treatments of the material and the corrosive properties. To evaluate the cytotoxicity, wide range of tests including the Sulforhodamine B assay and MTT tests, expression profiles, cell survival tests such as apoptotic test are used. The review compares the cell behaviour in contact with the material alloys composed of nickel and titanium with respect to different materials composition and different surface treatment that affects the ion release. Even though the results published so far are controversial, almost all data suggest sufficient biocompatibility in medical use.

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Abbreviations

ASCs:

Adipose stem cells

HUVECs:

Human umbilical vein endothelial cells

LDH test:

Lactatodeshidrogenasa test

NiTi:

Nitinol

NiTiCu:

Nitinol-copper

PBS:

Phosphate buffered saline

ROS-17:

Rat osteosarcoma

SRB:

Sulforhodamine B assay

Stst:

Stainless steel

TiN:

Titaniumnitride

TiO2 :

Titanium dioxide

VSMCs:

Vascular smooth muscle cells

XPS:

X-ray photoelectron spectroscopy

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Acknowledgement

This work was supported by the research project GA15-16336S of Grant agency of the Czech republic.

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  1. Institute of Pathological Physiology, Medical Faculty, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic

    Jana Sevcikova & Monika Pavkova Goldbergova

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  1. Jana Sevcikova
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  2. Monika Pavkova Goldbergova
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Correspondence to Monika Pavkova Goldbergova.

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Sevcikova, J., Pavkova Goldbergova, M. Biocompatibility of NiTi alloys in the cell behaviour. Biometals 30, 163–169 (2017). https://doi.org/10.1007/s10534-017-0002-5

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