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RETRACTED ARTICLE: Advanced oxidation protein products induce chondrocyte death through a redox-dependent, poly (ADP-ribose) polymerase-1-mediated pathway

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This article was retracted on 18 April 2017

Abstract

This study aimed to investigate the effect of AOPPs on apoptosis in human chondrocytes. Chondrocytes were treated with AOPPs. Cell death, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, reactive oxygen species (ROS) generation, and the expression of apoptotic proteins were detected in vitro. AOPPs levels were detected by colorimetric method. The results in vitro demonstrated that AOPPs induced cell death in human chondrocyte through a redox-dependent pathway, including RAGE-mediated, NADPH oxidase-dependent ROS generation, and poly (ADP-ribose) polymerase-1 (PARP-1) activation. Targeting AOPPs-induced cellular mechanisms might emerge as a promising therapeutic option for patients with RA.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81272042).

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Author notes

    Authors and Affiliations

    1. Department of Orthopaedics, The 175th Hospital of PLA, Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian, China

      Wenbin Ye

    2. Department of Orthopaedic Spinal Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China

      Zhaoming Zhong, Siyuan Zhu, Shuai Zheng, Hui Yu, Qian Wu, Zhen Lin & Jianting Chen

    3. Department of Orthopedic Joint Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

      Jun Xiao

    4. Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China

      Shaolian Song

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    1. Wenbin Ye
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    Correspondence to Jianting Chen.

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    Conflict of interest

    This manuscript is our original work. Not any part of the entire paper has been published or accepted elsewhere. It is not being submitted to any other journal. We also confirm that all listed authors have participated actively in this study. All authors have read the manuscript and have approved to submit to your journal. The authors do not have any possible conflicts of interest.

    Additional information

    Wenbin Ye and Siyuan Zhu have contributed equally to this work.

    The authors have requested to retract their paper. Their paper reported the advanced oxidation protein products (AOPPs) stimulation cause cell death of human chondrocyte of RA patients with PARP-1 over-expression and characterized the apoptosis mechanisms underlying the redox condition. Many of the figure panels in the paper summarize data from multiple experiments. The authors have now detected a number of errors in these panels. The authors believe that the most responsible course of action is to retract our paper. The authors sincerely apologize for their carelessness and poor arrangement of results and apologize to the community.

    An erratum to this article is available at http://dx.doi.org/10.1007/s10495-017-1373-3.

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    Ye, W., Zhong, Z., Zhu, S. et al. RETRACTED ARTICLE: Advanced oxidation protein products induce chondrocyte death through a redox-dependent, poly (ADP-ribose) polymerase-1-mediated pathway. Apoptosis 22, 86–97 (2017). https://doi.org/10.1007/s10495-016-1314-6

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    • DOI: https://doi.org/10.1007/s10495-016-1314-6

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