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Analysis of a semiparametric mixture model for competing risks

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Abstract

Semiparametric mixture regression models have recently been proposed to model competing risks data in survival analysis. In particular, Ng and McLachlan (Stat Med 22:1097–1111, 2003) and Escarela and Bowater (Commun Stat Theory Methods 37:277–293, 2008) have investigated the computational issues associated with the nonparametric maximum likelihood estimation method in a multinomial logistic/proportional hazards mixture model. In this work, we rigorously establish the existence, consistency, and asymptotic normality of the resulting nonparametric maximum likelihood estimators. We also propose consistent variance estimators for both the finite and infinite dimensional parameters in this model.

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References

  • Chang I.-S., Hsuing C.A., Wang M.-C., Wen C.-C. (2005) An asymptotic theory for the nonparametric maximum likelihood estimator in the Cox gene model. Bernoulli 11: 863–892

    Article  MathSciNet  MATH  Google Scholar 

  • Choi K.C., Zhou X. (2002) Large sample properties of mixture models with covariates for competing risks. Journal of Multivariate Analysis 82: 331–366

    Article  MathSciNet  MATH  Google Scholar 

  • Cox D.R. (1972) Regression models and life-tables (with discussion). Journal of the Royal Statistical Society, Series B 34: 187–220

    MATH  Google Scholar 

  • Dempster A.P., Laird N.M., Rubin D.B. (1977) Maximum likelihood from incomplete data via the EM algorithm. Journal of the Royal Statistical Society, Series B 39: 1–38

    MathSciNet  MATH  Google Scholar 

  • Dupuy J.-F., Escarela G. (2007) Modélisation de risques concurrents par un modèle de mélange semi-paramétrique. Comptes Rendus Mathématique. Académie des Sciences, Paris 344: 641–644

    MathSciNet  MATH  Google Scholar 

  • Dupuy J.-F., Mesbah M. (2004) Estimation of the asymptotic variance of semiparametric maximum likelihood estimators in the Cox model with a missing time-dependent covariate. Communications in Statistics: Theory and Methods 33: 1385–1401

    Article  MathSciNet  MATH  Google Scholar 

  • Dupuy J.-F., Grama I., Mesbah M. (2006) Asymptotic theory for the Cox model with missing time-dependent covariate. The Annals of Statistics 34: 903–924

    Article  MathSciNet  MATH  Google Scholar 

  • Escarela G., Bowater R. (2008) Fitting a semi-parametric mixture model for competing risks in survival data. Communications in Statistics: Theory and Methods 37: 277–293

    Article  MathSciNet  MATH  Google Scholar 

  • Fang H.-B., Li G., Sun J. (2005) Maximum likelihood estimation in a semiparametric logistic/proportional-hazards mixture model. Scandinavian Journal of Statistics 32: 59–75

    Article  MathSciNet  MATH  Google Scholar 

  • Klein, J. P., Bajorunaite, R. (2004). Inference for competing risks. In Advances in survival analysis, Handbook of statistics (Vol. 23, pp. 291–311). Amsterdam: Elsevier.

  • Klein J.P., Moeschberger M.L. (1997) Survival analysis: methods for censored and truncated data. Springer, New York

    Google Scholar 

  • Kosorok M.R., Song R. (2007) Inference under right censoring for transformation models with a change-point based on a covariate threshold. The Annals of Statistics 35: 957–989

    Article  MathSciNet  MATH  Google Scholar 

  • Kuk A.Y.C. (1992) A semiparametric mixture model for the analysis of competing risks data. Australian & New Zealand Journal of Statistics 34: 169–180

    Article  MathSciNet  MATH  Google Scholar 

  • Kuk A.Y.C., Chen C.-H. (1992) A mixture model combining logistic regression with proportional hazards regression. Biometrika 79: 531–541

    Article  MATH  Google Scholar 

  • Larson M.G., Dinse G.E. (1985) A mixture model for the regression analysis of competing risks data. Journal of the Royal Statistical Society, Series C 34: 201–211

    MathSciNet  Google Scholar 

  • Lu W. (2008) Maximum likelihood estimation in the proportional hazards cure model. Annals of the Institute of Statistical Mathematics 60: 545–574

    Article  MathSciNet  MATH  Google Scholar 

  • Lu W., Peng L. (2008) Semiparametric analysis of mixture regression models with competing risks data. Lifetime Data Analysis 14: 231–252

    Article  MathSciNet  Google Scholar 

  • Maller R.A., Zhou X. (2002) Analysis of parametric models for competing risks. Statistica Sinica 12: 725–750

    MathSciNet  MATH  Google Scholar 

  • Murphy S.A. (1994) Consistency in a proportional hazards model incorporating a random effect. The Annals of Statistics 22: 712–731

    Article  MathSciNet  MATH  Google Scholar 

  • Murphy S.A. (1995) Asymptotic theory for the frailty model. The Annals of Statistics 23: 182–198

    Article  MathSciNet  MATH  Google Scholar 

  • Naskar M., Das K., Ibrahim J.G. (2005) A semiparametric mixture model for analyzing clustered competing risks data. Biometrics 61: 729–737

    Article  MathSciNet  MATH  Google Scholar 

  • Ng S.K., McLachlan G.J. (2003) An EM-based semi-parametric mixture model approach to the regression analysis of competing-risks data. Statistics in Medicine 22: 1097–1111

    Article  Google Scholar 

  • Parner E. (1998) Asymptotic theory for the correlated gamma-frailty model. The Annals of Statistics 26: 183–214

    Article  MathSciNet  MATH  Google Scholar 

  • Peng Y. (2003) Fitting semiparametric cure models. Computational Statistics & Data Analysis 41: 481–490

    Article  MathSciNet  Google Scholar 

  • Slud E.V., Vonta F. (2004) Consistency of the NPML estimator in the right-censored transformation model. Scandinavian Journal of Statistics 31: 21–41

    Article  MathSciNet  MATH  Google Scholar 

  • Sy J.P., Taylor J.M.G. (2000) Estimation in a Cox proportional hazards cure model. Biometrics 56: 227–236

    Article  MathSciNet  MATH  Google Scholar 

  • Taylor J.M.G. (1995) Semi-parametric estimation in failure time mixture models. Biometrics 51: 899–907

    Article  MATH  Google Scholar 

  • Tsiatis A.A. (2006) Semiparametric theory and missing data. Springer, New York

    MATH  Google Scholar 

  • van der Vaart A.W. (1998) Asymptotic statistics. Cambridge University Press, Cambridge

    MATH  Google Scholar 

  • van der Vaart A.W., Wellner J.A. (1996) Weak convergence and empirical processes. Springer, New York

    MATH  Google Scholar 

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Correspondence to Jean-François Dupuy.

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Hernandez-Quintero, A., Dupuy, JF. & Escarela, G. Analysis of a semiparametric mixture model for competing risks. Ann Inst Stat Math 63, 305–329 (2011). https://doi.org/10.1007/s10463-009-0229-1

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  • DOI: https://doi.org/10.1007/s10463-009-0229-1

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