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Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?

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Abstract

This is a secondary analysis of data from a randomized trial of dually-focused interventions for nonadherent HIV patients with cocaine use disorders (Ingersoll et al. in Drug Alcohol Depend 116(1–3):177–187, 2011). We examined the relationships among baseline demographic, psychological, psychiatric, and behavioral characteristics and 6-months post-study ART adherence, log viral load (VL), ASI Drug Composite Score, and days using cocaine. We used the SAS GLMSELECT procedure to build multivariate models of each post-study outcome. Post-study ART adherence was related to 2 psychological variables; while logVL was related to 2 drug-related behaviors. ASI Drug Composite score was related to 2 psychiatric disorders, 1 demographic, and 1 psychological variable; in contrast, days using cocaine related to 1 behavioral and 3 psychological variables. Analyses show clear, robust relationships among behavioral, psychological and psychiatric diagnosis factors with post-study ART adherence and cocaine use outcomes. Future ART adherence interventions for cocaine users should consider tailoring to these patient characteristics.

Resumen

Este es un análisis secundario de los datos de un ensayo aleatorio de intervenciones dualmente enfocadas para los pacientes no adherentes VIH con trastornos por consumo de cocaína (Ingersoll et al. 2011). Examinamos las relaciones entre las características demográficas, psicológicos, psiquiátricos y conductuales de base y 6 meses post-estudio de adherencia ART, ingrese la carga viral (VL), ASI Drogas Composite Score, y días de consumir cocaína. Se utilizó el procedimiento SAS GLMSELECT para construir modelos multivariados de cada resultado post-estudio. Post-estudio de adherencia ART se relacionó con 2 variables psicológicas; mientras logVL se relacionó con 2 comportamientos relacionados con las drogas. Puntuación ASI Drogas Composite se relacionó con 2 trastornos psiquiátricos, 1 demográfica y 1 variable psicológica; en contraste, días de consumir cocaína relacionada con 1 conductual y 3 variables psicológicas. Los análisis muestran claros, relaciones sólidas entre los factores de diagnóstico conductuales, psicológicos y psiquiátricos con resultados de cumplimiento ART y de consumo de drogas post-estudio. Las intervenciones de cumplimiento ART futuras de los consumidores de drogas deben considerar la adaptación a estas características de los pacientes.

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Acknowledgments

This study was funded by NIH/NIDA by grant R01 DA016554.

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Authors and Affiliations

  1. Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, 310 Old Ivy Way, Suite 102, Charlottesville, VA, 22903, USA

    Gaia Read & Karen S. Ingersoll

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  1. Gaia Read
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  2. Karen S. Ingersoll
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Correspondence to Karen S. Ingersoll.

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Read, G., Ingersoll, K.S. Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?. AIDS Behav 20, 633–645 (2016). https://doi.org/10.1007/s10461-015-1119-6

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  • DOI: https://doi.org/10.1007/s10461-015-1119-6

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